Antimicrobial peptides: Defending the mucosal epithelial barrier

KF Johnstone, MC Herzberg - Frontiers in Oral Health, 2022 - frontiersin.org
The recent epidemic caused by aerosolized SARS-CoV-2 virus illustrates the importance
and vulnerability of the mucosal epithelial barrier against infection. Antimicrobial proteins …

A structural perspective on calprotectin as a ligand of receptors mediating inflammation and potential drug target

V Garcia, YR Perera, WJ Chazin - Biomolecules, 2022 - mdpi.com
Calprotectin, a heterodimer of S100A8 and S100A9 EF-hand calcium-binding proteins, is an
integral part of the innate immune response. Calprotectin (CP) serves as a ligand for several …

High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays

C Díaz-Perlas, B Ricken, L Farrera-Soler… - Nature …, 2023 - nature.com
Common inflammatory disorders such as ulcerative colitis and Crohn's disease are non-
invasively diagnosed or monitored by the biomarker calprotectin. However, current …

Hard–Soft Cooperativity of an Allosteric Tweezer

S Kang, H Lee, S Bae, D Lee - Organic Letters, 2023 - ACS Publications
Drawing inspiration from allosteric proteins, a zigzag-shaped π-conjugation was structurally
engineered into a tweezer-like ionophore having multiple disparate binding sites. When a …

Post-translational modifications on the metal-sequestering protein calprotectin

EM Nolan, JJY Peet - Biometals, 2023 - Springer
Abstract Human calprotectin (CP, S100A8/S100A9 oligomer) is an abundant neutrophil
protein that contributes to innate immunity by sequestering nutrient metal ions in the …

Genetically Engineered Liposwitch-Based Nanomaterials

MS Hossain, A Wang, S Anika, Z Zhang… - …, 2024 - ACS Publications
Fusion of intrinsically disordered and globular proteins is a powerful strategy to create
functional nanomaterials. However, the immutable nature of genetic encoding restricts the …

Spectroscopic and computational investigations of Cobalt (II) binding to the innate immune protein human calprotectin

MM Killian, MB Brophy, EM Nolan… - JBIC Journal of Biological …, 2024 - Springer
Human calprotectin (CP) is an innate immune protein that participates in the metal-
withholding response to infection by sequestering essential metal nutrients from invading …

A Turn-Off Fluorescent Strategy for Calprotectin Detection Based on the Inhibitory Effect of Calprotectin upon the Activity of Zn (Ⅱ)-Dependent DNAzyme

J Si, W Zhou, D Zhou, Y Fang, X Shen, C Zhu - Chemosensors, 2022 - mdpi.com
Calprotectin (CP) is an established biomarker that allows the noninvasive evaluation of
inflammation levels in the gastrointestinal tract of patients with inflammatory bowel disease …

NMR of proteins and nucleic acids

R Andrew Atkinson - 2024 - books.rsc.org
Writing this chapter each year continues to be a fascinating undertaking. The breadth of
applications of NMR to the study of biological macromolecules is astounding, with novel …

Advances in NMR spectroscopy of small molecules in solution

WF Reynolds, DC Burns - 2022 - books.rsc.org
This chapter discusses advances in small molecule NMR in solution and covers articles from
2020 or 2021. After a short introduction, the second, major, section covers the determination …