The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

The SLC22 family contains 13 functionally characterized human plasma membrane proteins
each with 12 predicted α-helical transmembrane domains. The family comprises organic …

The advent of highly active antiretroviral therapy (HAART), which constitutes HIV protease
inhibitors, nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase …

Concentrative nucleoside transporters (CNT; SLC28) and equilibrative nucleoside
transporters (ENT; SLC29) mediate the uptake of natural nucleosides and a variety of …

In patients infected by HIV, the efficacy of highly active antiretroviral (ARV) therapy through
the blockade of different steps of the retrovirus life cycle is now well established. As HIV is a …

Immune regulatory metabolites are key features of the tumor microenvironment (TME), yet
with a few exceptions, their identities remain largely unknown. Here, we profiled tumor and T …

Abstract BACKGROUND AND AIMS: The standard palliative chemotherapy for pancreatic
ductal adenocarcinoma (PDAC) is gemcitabine-based chemotherapy; however, PDAC still …

Nucleoside and nucleobase analogs are currently used in the treatment of solid tumors,
lymphoproliferative diseases, viral infections such as hepatitis and AIDS, and some …

Membrane transporters play critical roles in moving a variety of anticancer drugs across
cancer cell membrane, thereby determining chemotherapy efficacy and/or toxicity. The …

OCTN is a small subfamily of membrane transport proteins that belongs to the larger SLC22
family. Two of the three members of the subfamily, namely, OCTN2 and OCTN1, are present …