Mechanical determinants of chromatin topology and gene expression

RK Jha, D Levens, F Kouzine - Nucleus, 2022 - Taylor & Francis
The compaction of linear DNA into micrometer-sized nuclear boundaries involves the
establishment of specific three-dimensional (3D) DNA structures complexed with histone …

Recent advances in fluorescence recovery after photobleaching for decoupling transport and kinetics of biomacromolecules in cellular physiology

N Cai, ACK Lai, K Liao, PR Corridon, DJ Graves… - Polymers, 2022 - mdpi.com
Among the new molecular tools available to scientists and engineers, some of the most
useful include fluorescently tagged biomolecules. Tools, such as green fluorescence protein …

Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer–promoter interactions

K Wang, M Escobar, J Li, B Mahata, J Goell… - Nucleic Acids …, 2022 - academic.oup.com
Nuclease-inactivated CRISPR/Cas-based (dCas-based) systems have emerged as powerful
technologies to synthetically reshape the human epigenome and gene expression. Despite …

Dynamical phase transition in models that couple chromatin folding with histone modifications

A Sood, G Schuette, B Zhang - Physical Review E, 2024 - APS
Genomic regions can acquire heritable epigenetic states through unique histone
modifications, which lead to stable gene expression patterns without altering the underlying …

Power-law behavior of transcriptional bursting regulated by enhancer–promoter communication

Z Wang, Z Zhang, S Luo, T Zhou, J Zhang - Genome Research, 2024 - genome.cshlp.org
Revealing how transcriptional bursting kinetics are genomically encoded is challenging
because genome structures are stochastic at the organization level and are suggestively …

Approaches to characterize chromatin subcompartment organization in the cell nucleus

R Weinmann, L Frank, K Rippe - Current Opinion in Structural Biology, 2023 - Elsevier
The mechanism of self-organization of chromatin subcompartments on the 0.1–1 μm scale
and their impact on genome-associated activities has long been a key aspect of research on …

Roles of chromatin remodelling and molecular heterogeneity in therapy resistance in glioblastoma

HM Chen, A Nikolic, D Singhal, M Gallo - Cancers, 2022 - mdpi.com
Simple Summary We review the role of chromatin and epigenetic dysregulation in therapy
resistance in glioblastoma. We discuss how epigenetic and genetic forces may cooperate to …

Integrating bioelectronics with cell-based synthetic biology

J Rivnay, R Raman, JT Robinson, C Schreib… - Nature Reviews …, 2025 - nature.com
Biohybrid devices based on engineered cells interfaced with bioelectronics represent a
promising union where the strengths of each field can be synergistically combined, resulting …

The BAF chromatin remodeling complexes: structure, function, and synthetic lethalities

J Varga, M Kube, K Luck, S Schick - Biochemical Society …, 2021 - portlandpress.com
BAF complexes are multi-subunit chromatin remodelers, which have a fundamental role in
genomic regulation. Large-scale sequencing efforts have revealed frequent BAF complex …

T Cells Spatially Regulate B Cell Receptor Signaling in Lymphomas through H3K9me3 Modifications

LS Britto, D Balasubramani, S Desai… - Advanced …, 2024 - Wiley Online Library
Activated B cell‐like diffuse large B‐cell lymphoma (ABC‐DLBCL) is a subtype associated
with poor survival outcomes. Despite identifying therapeutic targets through molecular …