HDACs (histone deacetylases) are a group of enzymes that deacetylate histones as well as
non-histone proteins. They are known as modulators of gene transcription and are …

Over two decades of research have demonstrated that the peptide hormone endothelin-1
(ET-1) plays multiple, complex roles in cardiovascular, neural, pulmonary, reproductive, and …

Non-alcoholic steatohepatitis (NASH) is an epidemic metabolic disease with limited
therapeutic strategies. Cumulative data support the pivotal role of gut microbiota in NASH …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer. The characteristic
excessive stromatogenesis accompanying the growth of this tumor is believed to contribute …

Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-
1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a …

The functions of the gut are closely related to those of many other organs in the human body.
Indeed, the gut microbiota (GM) metabolize several nutrients and compounds that, once …

Abstract Cancer-associated fibroblasts (CAFs), a significant component of the tumor
microenvironment (TME), contribute to cancer progression through the secretion of …

Hepatic stellate cell (HSC) activation is a pivotal step in the pathogenesis of liver fibrosis.
The clarification of this transdifferentiation process is therefore important for the development …

Stromal cells of the tumor microenvironment have been shown to play important roles in
both supporting and limiting cancer growth. The altered phenotype of tumor-associated …

Simple Summary Pancreatic cancer is a devasting disease that has unfortunately proven
very difficult to treat. Exploring new therapeutic options and getting an early diagnosis is …