Annexin‐A1: the culprit or the solution?

L Kelly, S McGrath, L Rodgers, K McCall… - …, 2022 - Wiley Online Library
Annexin‐A1 has a well‐defined anti‐inflammatory role in the innate immune system, but its
function in adaptive immunity remains controversial. This glucocorticoid‐induced protein has …

Biologically informed deep learning to query gene programs in single-cell atlases

M Lotfollahi, S Rybakov, K Hrovatin… - Nature Cell …, 2023 - nature.com
The increasing availability of large-scale single-cell atlases has enabled the detailed
description of cell states. In parallel, advances in deep learning allow rapid analysis of newly …

The multifaceted role of annexin A1 in viral infections

F Resende, S Araújo, LP Tavares, MM Teixeira… - Cells, 2023 - mdpi.com
Dysregulated inflammatory responses are often correlated with disease severity during viral
infections. Annexin A1 (AnxA1) is an endogenous pro-resolving protein that timely regulates …

Resolution pharmacology and the treatment of infectious diseases

VV Costa, F Resende, EM Melo… - British Journal of …, 2024 - Wiley Online Library
Inflammation is elicited by the host in response to microbes, and is believed to be essential
for protection against infection. However, we have previously hypothesized that excessive or …

Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model

I Aknouch, A Sridhar, E Freeze… - Life Science …, 2022 - life-science-alliance.org
Human milk is important for antimicrobial defense in infants and has well demonstrated
antiviral activity. We evaluated the protective ability of human milk against severe acute …

Pro-resolving therapies as potential adjunct treatment for infectious diseases: Evidence from studies with annexin A1 and angiotensin-(1-7)

LP Tavares, EM Melo, LP Sousa, MM Teixeira - Seminars in immunology, 2022 - Elsevier
Infectious diseases, once believed to be an eradicable public health threat, still represent a
leading cause of death worldwide. Environmental and social changes continuously favor the …

Predictive Value of Annenxin A1 for Disease Severity and Prognosis in Patients with Community-Acquired Pneumonia

M Gu, X Han, X Liu, F Sui, Q Zhang, S Pan - Diagnostics, 2023 - mdpi.com
This prospective, single-center study evaluated the clinical utility of annenxin (Anx) A1 level
as a biomarker for determining the severity of illness and predicting the risk of death in …

Comparative spatial transcriptomic profiling of severe acute respiratory syndrome coronavirus 2 Delta and Omicron variants infections in the lungs of cynomolgus …

T Oh, G Kim, SH Baek, YM Woo, BS Koo… - Journal of Medical …, 2023 - Wiley Online Library
Recently emerging severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
Omicron variants are generally less pathogenic than previous strains. However, elucidating …

Biologically informed deep learning to infer gene program activity in single cells

M Lotfollahi, S Rybakov, K Hrovatin, S Hediyeh-zadeh… - BioRxiv, 2022 - biorxiv.org
The increasing availability of large-scale single-cell datasets has enabled the detailed
description of cell states across multiple biological conditions and perturbations. In parallel …

Tissue plasminogen activator receptor ANXA2 and its complementary regulator anti-inflammatory ANXA1 as prognostic indicators of inflammatory response in COVID …

RD Shenoy, N Kuriakose, M Vijaykrishnaraj, P Patil… - Immunobiology, 2023 - Elsevier
COVID-19 patients demonstrating hyperactive immunologic response appear to have a
severe illness with a poor prognosis. This study hypothesizes that the pro-inflammatory …