Pre-eclampsia: pathogenesis, novel diagnostics and therapies

EA Phipps, R Thadhani, T Benzing… - Nature Reviews …, 2019 - nature.com
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …

A global view of hypertensive disorders and diabetes mellitus during pregnancy

L Jiang, K Tang, LA Magee, P von Dadelszen… - Nature Reviews …, 2022 - nature.com
Two important maternal cardiometabolic disorders (CMDs), hypertensive disorders in
pregnancy (HDP)(including pre-eclampsia) and gestational diabetes mellitus (GDM), result …

[HTML][HTML] FIGO (international Federation of Gynecology and obstetrics) initiative on fetal growth: best practice advice for screening, diagnosis, and management of fetal …

N Melamed, A Baschat, Y Yinon… - … of Gynaecology and …, 2021 - ncbi.nlm.nih.gov
Fetal growth restriction (FGR) is defined as the failure of the fetus to meet its growth potential
due to a pathological factor, most commonly placental dysfunction. Worldwide, FGR is a …

Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction

A Colson, P Sonveaux, F Debiève… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Prevention of preeclampsia

M Ma'ayeh, MM Costantine - Seminars in Fetal and Neonatal Medicine, 2020 - Elsevier
Preeclampsia is an obstetric disorder that affects 3–8% of pregnant women and remains a
leading cause of short-and long-term neonatal and maternal morbidity and mortality …

Use of metformin to prolong gestation in preterm pre-eclampsia: randomised, double blind, placebo controlled trial

CA Cluver, R Hiscock, EH Decloedt, DR Hall, S Schell… - Bmj, 2021 - bmj.com
Objective To evaluate whether extended release metformin could be used to prolong
gestation in women being expectantly managed for preterm pre-eclampsia. Design …

Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia

S Tong, J Tu'uhevaha, R Hastie, F Brownfoot… - American journal of …, 2022 - Elsevier
There has been increasing research momentum to identify new therapeutic agents for the
prevention or treatment of preeclampsia, drugs that can affect the underlying disease …

[HTML][HTML] A randomized controlled trial of low-dose aspirin for the prevention of preeclampsia in women at high risk in China

L Lin, J Huai, B Li, Y Zhu, J Juan, M Zhang… - American Journal of …, 2022 - Elsevier
Background Low-dose aspirin has been the most widely studied preventive drug for
preeclampsia. However, guidelines differ considerably from country to country regarding the …

Atypical preeclampsia before 20 weeks of gestation—a systematic review

J Modzelewski, I Siarkowska, J Pajurek-Dudek… - International Journal of …, 2023 - mdpi.com
This systematic review was conducted to gather evidence of preeclampsia occurring before
the 20th week of gestation, additionally considering the role of PLGF and sFlt-1 in the …

Novel interventions for the prevention of preeclampsia

M Ma'ayeh, KM Rood, D Kniss… - Current hypertension …, 2020 - Springer
Abstract Purpose of Review To review the rationale and biological plausibility and discuss
the current research on novel interventions for the prevention of preeclampsia. Recent …