Glioblastoma multiforme (GBM) remains one of the most aggressive and lethal forms of brain
cancer, characterized by rapid proliferation and diffuse infiltration into the surrounding brain …

[18 F]-dihydroxyphenylalanine ([18 F] FDOPA) is a radiopharmaceutical used in a broad
spectrum of diseases, including neuroendocrine tumors (NETs), congenital hyperinsulinism …

Photoredox is a powerful synthetic tool in organic chemistry and has been widely used in
various fields, including nuclear medicine and molecular imaging. In particular, acridinium …

In this study, we introduce a practical methodology for the synthesis of PET probes by
seamlessly combining flow chemistry with photoredox radiofluorination. The clinical PET …

Abstract Radiotracer 3, 4-dihydroxy-6-[18 F] fluoro-L-phenylalanine (L-6-[18 F] fluorodopa or
[18 F] FDOPA) is widely used for PET imaging of dopamine metabolism in several diseases …

Parkinson's disease (PD) is one of the most common neurodegenerative diseases with a
complex pathogenesis. Aggregations formed by abnormal deposition of alpha-synuclein …

Direct fluorination of a tosylate or mesylate precursor has been a wide-spread and reliable
way for radio-fluorination. This approach can be difficult to achieve when the precursor …

Positron emission tomography (PET) is a noninvasive molecular imaging technique that
utilizes biologically active radiolabeled compounds to image biochemical processes. As …

Purpose The clinical demand of 6-l-[18F] FDOPA is gaining rapidly for imaging
neurodegenerative diseases by using positron emission tomography. Hence, large-scale …

This guideline outlines the use of 3, 4-dihydroxy-6-18 F-fluoro-L-phenylalanine positron
emission tomography/computed tomography for the diagnosis and management of …