Single-cell and spatial multimodal technologies have propelled discoveries of the solid
tumor microenvironment (TME) molecular features and their correlation with clinical …

In the realm of cancer research, the tumor microenvironment (TME) plays a crucial role in
tumor initiation and progression, shaped by complex interactions between cancer cells and …

Immune-checkpoint blockade has revolutionized cancer treatment, but some cancers, such
as acute myeloid leukemia (AML), do not respond or develop resistance. A potential mode of …

Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas …

Genomic profiles and prognostic biomarkers in patients with acute myeloid leukemia (AML)
from ancestry-diverse populations are underexplored. We analyzed the exomes and …

Cancer driver mutations often show distinct temporal acquisition patterns, but the biological
basis for this, if any, remains unknown. RAS mutations occur invariably late in the course of …

Abstract Analysis of the human hematopoietic progenitor compartment is being transformed
by single-cell multimodal approaches. Cellular indexing of transcriptomes and epitopes by …

Myeloid malignancies are devastating hematologic cancers with limited therapeutic options.
Inflammation is emerging as a novel driver of myeloid malignancy, with important …

Inflammation in the bone marrow (BM) microenvironment is a constitutive component of
leukemogenesis in acute myeloid leukemia (AML). Current evidence suggests that both …

Interferon gamma (IFNγ) is a critical cytokine known for its diverse roles in immune
regulation, inflammation, and tumor surveillance. However, while IFNγ levels were elevated …