Background Chronic alcohol exposure (CAE) during late adolescence increases the risk of
anxiety development. Alcohol-induced prefrontal cortex (PFC) microglial activation …

The brain, one of the most resilient organs of the body is highly enriched in lipid content,
suggesting the essential role of lipids in brain physiological activities. Lipids constitute an …

Emotional behavior, memory, and learning have been associated with alterations in the
immune system in neuropsychiatric and neurodegenerative diseases. In recent years …

Simple Summary Alzheimer's disease (AD) is a complex, multifactorial disease where
numerous components, such as environment, lifestyle, comorbidities, and genetic …

Endocannabinoid system activity declines with age in the hippocampus, along with the
density of the cannabinoid receptor type-1 (CB1). This process might contribute to brain …

Acute gastrointestinal (GI) inflammation induces neuroplasticity that produces long‐lasting
changes in gut motor function and pain. The endocannabinoid system is an attractive target …

Background Ischemic stroke is a significant cause of death and disability with a limited
treatment time window. The reduction of early glutamate excitotoxicity using neuroprotective …

The endocannabinoid system (ECS) is composed of endogenous cannabinoids;
components involved in their synthesis, transport, and degradation; and an expansive …

In patients with multiple sclerosis (MS), a typical pattern of muscle tone alteration, known as
spasticity, is frequently observed in combination with other signs or symptoms such as …

Seizures is a prevalent neurological disorder with a largely elusive pathogenesis. In this
study, we identified the key gene RACK1 and its novel mutation RACK1-p. L206P as being …