The in vivo fate of polymeric micelles

Y Cai, J Qi, Y Lu, H He, W Wu - Advanced Drug Delivery Reviews, 2022 - Elsevier
This review aims to provide a systemic analysis of the in vivo, as well as subcellular, fate of
polymeric micelles (PMs), starting from the entry of PMs into the body. Few PMs are able to …

Investigating supramolecular systems using Förster resonance energy transfer

AJP Teunissen, C Pérez-Medina, A Meijerink… - Chemical Society …, 2018 - pubs.rsc.org
Supramolecular systems have applications in areas as diverse as materials science,
biochemistry, analytical chemistry, and nanomedicine. However, analyzing such systems …

The blood clearance kinetics and pathway of polymeric micelles in cancer drug delivery

X Sun, G Wang, H Zhang, S Hu, X Liu, J Tang… - ACS nano, 2018 - ACS Publications
Polymer micelles are one of the most investigated nanocarriers for drug delivery; many have
entered clinical trials and some are in clinic use, but their delivery systems have not yet …

Cell-specific metabolic reprogramming of tumors for bioactivatable ferroptosis therapy

Y Li, M Li, L Liu, C Xue, Y Fei, X Wang, Y Zhang… - ACS …, 2022 - ACS Publications
Ferroptosis is a nonapoptotic iron-dependent cell death pathway with a significant clinical
potential, but its translation is impeded by lack of tumor-specific ferroptosis regulators and …

Design, synthesis, and nanostructure-dependent antibacterial activity of cationic peptide amphiphiles

N Rodrigues de Almeida, Y Han, J Perez… - … applied materials & …, 2018 - ACS Publications
The development of bacterial resistant strains is a global health concern. Designing
antibiotics that limit the rise of pathogenic resistance is essential to efficiently treat …

Translatable high drug loading drug delivery systems based on biocompatible polymer nanocarriers

W Chen, S Zhou, L Ge, W Wu, X Jiang - Biomacromolecules, 2018 - ACS Publications
Most nanocarriers possess low drug loading, resulting in frequently repeated administration
and thereby high cost and increased side effects. Furthermore, the characteristics of …

Polycation architecture and assembly direct successful gene delivery: micelleplexes outperform polyplexes via optimal DNA packaging

Z Tan, Y Jiang, W Zhang, L Karls… - Journal of the …, 2019 - ACS Publications
Cellular delivery of biomacromolecules is vital to medical research and therapeutic
development. Cationic polymers are promising and affordable candidate vehicles for these …

Near‐infrared fluorophores with absolute aggregation‐caused quenching and negligible fluorescence re‐illumination for in vivo bioimaging of nanocarriers

Y Cai, X Ji, Y Zhang, C Liu, Z Zhang, Y Lv, X Dong… - …, 2023 - Wiley Online Library
Environment‐responsive fluorophores with aggregation‐caused quenching (ACQ)
properties have been applied to track nanocarriers with reduced artefacts caused by …

Tools to enable the study and translation of supramolecular amphiphiles

T Allam, DE Balderston, MK Chahal… - Chemical Society …, 2023 - pubs.rsc.org
This tutorial review focuses on providing a summary of the key techniques used for the
characterisation of supramolecular amphiphiles and their self-assembled aggregates; from …

Elucidating the stability of single-chain polymeric nanoparticles in biological media and living cells

L Deng, L Albertazzi, ARA Palmans - Biomacromolecules, 2021 - ACS Publications
The controlled folding of synthetic polymer chains into single-chain polymeric nanoparticles
(SCPNs) of defined size and shape in water is a viable way to create compartmentalized …