The hypothesis that adequate vitamin D nutrition can contribute to the prevention of multiple
sclerosis (MS) was originally proposed to explain the geographical distribution of MS, but …

Osteoporosis is a metabolic bone disorder that is characterized by low bone mass and micro-
architectural deterioration of bone tissue. Fractures of the proximal femur, the vertebrae and …

Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of
osteoporosis and the assessment of fracture risk. We performed meta-analysis of five …

Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …

Background Osteoporosis is diagnosed by the measurement of bone mineral density, which
is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Background: Osteoporosis is a highly heritable trait. Many candidate genes have been
proposed as being involved in regulating bone mineral density (BMD). Few of these findings …

Genomic technologies have evolved rapidly contributing to the understanding of diseases.
Genome-wide association studies (GWAS) and whole-exome sequencing have aided the …

Background Osteoporosis is characterized by low bone mass and compromised bone
structure, heritable traits that contribute to fracture risk. There have been no genome-wide …

Context Mutations in the low-density lipoprotein receptor–related protein 5 (LRP5) gene
cause rare syndromes characterized by altered bone mineral density (BMD). More common …