Defects in chromatin modifiers and remodelers have been described both for hematological
and solid malignancies, corroborating and strengthening the role of epigenetic aberrations …

Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …

Cardiac endothelium communicates closely with adjacent cardiac cells by multiple cytokines
and plays critical roles in regulating fibroblasts proliferation, activation, and collagen …

Abstract The chromosomal translocation t (8; 21) and the resulting oncofusion gene
AML1/ETO have long served as a prototypical genetic lesion to model and understand …

The fusion oncogene RUNX1/RUNX1T1 encodes an aberrant transcription factor, which
plays a key role in the initiation and maintenance of acute myeloid leukemia. Here we show …

Abstract The ETV6-RUNX1 onco-fusion arises in utero, initiating a clinically silent pre-
leukemic state associated with the development of pediatric B-acute lymphoblastic leukemia …

Abstract Changes in gene regulation and expression govern orderly transitions from
hematopoietic stem cells to terminally differentiated blood cell types. These transitions are …

Myeloid master regulator CCAAT enhancer-binding protein alpha (C/EBPα) is deregulated
by multiple mechanisms in leukemia. Inhibition of C/EBPα function plays pivotal roles in …

The ERG (ETS-related gene) transcription factor is linked to various types of cancer,
including leukemia. However, the specific ERG domains and co-factors contributing to …