In 1912, Hashimoto described four women in whom the thyroid gland was enlarged and
appeared to have been transformed into lymphoid tissue (“struma lymphomatosa”). 1 …

Infants and the elderly share a high vulnerability to infections and therefore have specific
immunization requirements. Inducing potent and sustained B-cell responses is as …

Most aging individuals die from atherosclerosis, cancer, or dementia; but in the oldest old,
loss of muscle strength resulting in frailty is the limiting factor for an individual's chances of …

Background. The compression of morbidity hypothesis predicts that, in order to achieve their
extreme old age, centenarians markedly delay or even escape diseases that would …

We carefully assessed thyroid status and goiter by ultrasound in 1411 subjects virtually
representing the entire resident population of Pescopagano, an iodine-deficient village of …

The trace element zinc is essential for the immune system, and zinc deficiency affects
multiple aspects of innate and adaptive immunity. There are remarkable parallels in the …

According to the remodeling theory of aging we proposed several years ago, the current
data on human immunosenescence depicts a complex scenario where clonotypical …

Recent observations indicate that immunosenescence is not accompanied by an
unavoidable and progressive deterioration of the immune function, but is rather the result of …

The contribution of the immune system to healthy aging and longevity is still an open
question. For this reason, several immune parameters (T, B, and natural killer [NK] cell …

There are more than 300 theories to explain the aging phenomenon. Many of them originate
from the study of changes that accumulate with time. Among all the theories, the free radical …