Twenty years ago, Rho-kinase was identified as an important downstream effector of the
small GTP-binding protein, RhoA. Thereafter, a series of studies demonstrated the important …

Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Abnormal smooth-muscle contractility may be a major cause of disease states such as
hypertension, and a smooth-muscle relaxant that modulates this process would be useful …

The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC)
phosphorylation, which results in contraction of smooth muscle and interaction of actin and …

The small GTPase Rho is implicated in physiological functions associated with actin-myosin
filaments such as cytokinesis, cell motility, and smooth muscle contraction. We have recently …

Somlyo, Andrew P., and Avril V. Somlyo. Ca2+ Sensitivity of Smooth Muscle and Nonmuscle
Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase. Physiol Rev 83 …

Activated rhoA, a ras-related GTP-binding protein, stimulates the appearance of stress
fibers, focal adhesions, and tyrosine phosphorylation in quiescent cells (Ridley, AJ, and A …

The colorimetric and fluorescent Schiff base sensors have proven to be powerful tools in the
detection of metal ions due to their simplicity, low cost, rapid photophysical response, high …

▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix
developed by cells in culture. They provide a structural link between the actin cytoskeleton …

Smooth muscle cells in the walls of many organs are vital for most bodily functions, and their
abnormalities contribute to a range of diseases. Although based on a sliding-filament …