Sarcopenia and frailty in decompensated cirrhosis
In patients with decompensated cirrhosis, sarcopenia and frailty are prevalent. Although
several definitions exist for these terms, in the field of hepatology, sarcopenia has commonly …
several definitions exist for these terms, in the field of hepatology, sarcopenia has commonly …
Liver transplantation in the patient with physical frailty
Frailty is a decline in functional reserve across multiple physiological systems. A key
component of frailty is sarcopenia, which denotes a loss of skeletal muscle mass and …
component of frailty is sarcopenia, which denotes a loss of skeletal muscle mass and …
Deregulation of ribosome biogenesis in nitrite-oxidizing bacteria leads to nitrite accumulation
W Xiong, Y Ye, D He, S He, Y Xiang… - Environmental …, 2023 - ACS Publications
Nitrite (NO2–) accumulation caused by nitrite-oxidizing bacteria (NOB) inhibition in
nitrification is a double-edged sword, ie, a disaster in aquatic environments but a hope for …
nitrification is a double-edged sword, ie, a disaster in aquatic environments but a hope for …
Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy
Protein synthesis and autophagy are regulated by cellular ATP content. We tested the
hypothesis that mitochondrial dysfunction, including generation of reactive oxygen species …
hypothesis that mitochondrial dysfunction, including generation of reactive oxygen species …
[HTML][HTML] Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence
Ammonia is a cytotoxic metabolite with pleiotropic molecular and metabolic effects, including
senescence induction. During dysregulated ammonia metabolism, which occurs in chronic …
senescence induction. During dysregulated ammonia metabolism, which occurs in chronic …
Dysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction and senescence by inhibiting sirtuin‐mediated deacetylation
Perturbed metabolism of ammonia, an endogenous cytotoxin, causes mitochondrial
dysfunction, reduced NAD+/NADH (redox) ratio, and postmitotic senescence. Sirtuins are …
dysfunction, reduced NAD+/NADH (redox) ratio, and postmitotic senescence. Sirtuins are …
Influencing factors and molecular pathogenesis of sarcopenia and osteosarcopenia in chronic liver disease
C Saeki, A Tsubota - Life, 2021 - mdpi.com
The liver plays a pivotal role in nutrient/energy metabolism and storage, anabolic hormone
regulation, ammonia detoxification, and cytokine production. Impaired liver function can …
regulation, ammonia detoxification, and cytokine production. Impaired liver function can …
Exercise-induced increases in insulin sensitivity after bariatric surgery are mediated by muscle extracellular matrix remodeling
Exercise seems to enhance the beneficial effect of bariatric (Roux-en-Y gastric bypass
[RYGB]) surgery on insulin resistance. We hypothesized that skeletal muscle extracellular …
[RYGB]) surgery on insulin resistance. We hypothesized that skeletal muscle extracellular …
Identification of FMR1-regulated molecular networks in human neurodevelopment
M Li, J Shin, RD Risgaard, MJ Parries, J Wang… - Genome …, 2020 - genome.cshlp.org
RNA-binding proteins (RNA-BPs) play critical roles in development and disease to regulate
gene expression. However, genome-wide identification of their targets in primary human …
gene expression. However, genome-wide identification of their targets in primary human …
Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF …
Y Huang, Z Li, E Lin, P He, G Ru - Experimental & Molecular Medicine, 2021 - nature.com
In vitro fertilization (IVF) increases the risk of tumorigenesis in offspring. The increased
oxidative damage during IVF may be involved in tumor formation. However, the molecular …
oxidative damage during IVF may be involved in tumor formation. However, the molecular …