Hypoxia–ischemia before or around the time of birth occurs in approximately 2/1000 live
births and is associated with a high risk of death or lifelong disability. Therapeutic …

Acute hypoxic–ischemic encephalopathy around the time of birth remains a major cause of
death and life-long disability. The key insight that led to the modern revival of studies of …

Background Unconscious survivors of out-of-hospital cardiac arrest have a high risk of death
or poor neurologic function. Therapeutic hypothermia is recommended by international …

Importance Hypothermia initiated at less than 6 hours after birth reduces death or disability
for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our …

Background Hypothermia is protective against brain injury after asphyxiation in animal
models. However, the safety and effectiveness of hypothermia in term infants with …

Hypothermia has been proposed as a neuroprotective strategy. However, short-term cooling
after hypoxia-ischemia is effective only if started immediately during resuscitation. The aim of …

Background A hypoxic-ischaemic insult occurring around the time of birth may result in an
encephalopathic state characterised by the need for resuscitation at birth, neurological …

Therapeutic hypothermia holds promise as a rescue neuroprotective strategy for hypoxic-
ischemic injury, but the incidence of severe neurologic sequelae with hypothermia is …

Background On the basis of mixed results from previous trials, we assessed whether
therapeutic hypothermia for 48–72 h with slow rewarming improved mortality in children …

Aims. To determine the practicality and safety of head cooling with mild or minimal systemic
hypothermia in term neonates with moderate to severe hypoxic-ischemic encephalopathy …