Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various
cellular processes and is aberrantly activated in cancers, contributing to the occurrence and …

Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Apoptosis is a form of cell death by which the body maintains the homeostasis of the internal
environment. Apoptosis is an initiative cell death process that is controlled by genes and is …

Biomarkers-guided precision therapeutics has revolutionized the clinical development and
administration of molecular-targeted anticancer agents. Tailored precision cancer therapy …

Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality
worldwide. Its complexity is influenced by various signal transduction networks that govern …

Cancer is one of the primary causes of death worldwide, and its incidence continues to
increase yearly. Despite significant advances in research, the search for effective and …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …