Salmonellae are important causes of enteric diseases in all vertebrates. Characterization of
the molecular mechanisms that underpin the interactions of salmonellae with their animal …

Rab proteins are the major regulators of vesicular trafficking in eukaryotic cells. Their activity
can be tightly controlled within cells: Regulated by guanine nucleotide exchange factors …

Endocytosis marks the entry of internalized receptors into the complex network of endocytic
trafficking pathways. Endocytic vesicles are rapidly targeted to a distinct membrane-bound …

Salmonella pathogenesis relies upon the delivery of over thirty specialised effector proteins
into the host cell via two distinct type III secretion systems. These effectors act in concert to …

The mammalian innate immune response provides a barrier against invading pathogens.
Innate immune mechanisms are used by the host to respond to a range of bacterial …

Membrane and protein traffic in the secretory and endocytic pathways is mediated by
vesicular transport. Recent studies of certain key regulators of vesicular transport, the Rab …

Microbial pathogens possess a diversity of weapons that disrupt host homeostasis and
immune defenses, thus resulting in the establishment of infection. The best-characterized …

Intracellular bacterial pathogens have evolved highly specialized mechanisms to enter and
survive within their eukaryotic hosts. In order to do this, bacterial pathogens need to avoid …

The facultative intracellular pathogen Salmonella enterica resides in a special membrane
compartment of the host cell and modifies its host to achieve intracellular survival and …

The Gram‐negative pathogen Salmonella enterica can survive and replicate within a variety
of mammalian cells. Regardless of the cell type, internalized bacteria survive and replicate …