RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression

S Rezatabar, A Karimian, V Rameshknia… - Journal of cellular …, 2019 - Wiley Online Library
Mitogen‐activated protein kinase (MAPK) signaling pathways organize a great constitution
network that regulates several physiological processes, like cell growth, differentiation, and …

[PDF][PDF] Wnt signaling pathway in development and cancer

B Taciak, I Pruszynska, L Kiraga, M Bialasek… - J Physiol …, 2018 - academia.edu
Wnt signaling pathway is one of the most important signaling pathways. The complexity of
Wnt signals and their functional role is crucial in development and growth. It is the most …

Nrf2 modulation in breast cancer

S Ghareghomi, M Habibi-Rezaei, M Arese, L Saso… - Biomedicines, 2022 - mdpi.com
Reactive oxygen species (ROS) are identified to control the expression and activity of
various essential signaling intermediates involved in cellular proliferation, apoptosis, and …

Modulating tumor hypoxia by nanomedicine for effective cancer therapy

R Jahanban‐Esfahlan, M de la Guardia… - Journal of cellular …, 2018 - Wiley Online Library
Hypoxia, a characteristic feature of tumors, is indispensable to tumor angiogenesis,
metastasis, and multi drug resistance. Hypoxic avascular regions, deeply embedded inside …

CRISPR/Cas9 technology as a potent molecular tool for gene therapy

A Karimian, K Azizian, H Parsian… - Journal of cellular …, 2019 - Wiley Online Library
Clustered regularly interspaced short palindromic repeats/CRISPR‐associated nuclease 9
(CRISPR‐Cas9) is an RNA‐guided gene editing tool which offers several advantageous …

53BP1: A key player of DNA damage response with critical functions in cancer

M Mirza-Aghazadeh-Attari, A Mohammadzadeh… - DNA repair, 2019 - Elsevier
Maintenance of genome integrity and stability is a critical responsibility of the DNA damage
response (DDR) within cells, such that any disruption in this kinase-based signaling …

Oxidative stress: glutathione and its potential to protect Methionine-35 of Aβ peptide from oxidation

PK Mandal, RG Roy, A Samkaria - ACS omega, 2022 - ACS Publications
Alzheimer's disease (AD) is the most common neurodegenerative disorder with
heterogeneous etiology. Intracellular neurofibrillary tangles caused by tau (τ) protein …

Ginkgetin: A natural biflavone with versatile pharmacological activities

M Adnan, A Rasul, G Hussain, MA Shah… - Food and Chemical …, 2020 - Elsevier
Natural products, being richly endowed with curative powers, have become spotlight for
biomedical and pharmaceutical research to develop novel therapeutics during recent years …

The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine

M Majidinia, J Aghazadeh… - Journal of cellular …, 2018 - Wiley Online Library
Regenerative medicine is a translational field which combines tissue engineering and
molecular biology to construct spare organs or help injured or defective tissues to …

Alteration in Wnt signaling mediates induction of transgenerational toxicity of polystyrene nanoplastics in C. elegans

R Xu, X Hua, Q Rui, D Wang - NanoImpact, 2022 - Elsevier
Polystyrene nanoparticles (PS-NPs) have a potential toxicity on offspring after the exposure.
However, the molecular basis for PS-NP in inducing transgenerational toxicity remains …