Complex functions of Gcn5 and Pcaf in development and disease
A wealth of biochemical and cellular data, accumulated over several years by multiple
groups, has provided a great degree of insight into the molecular mechanisms of actions of …
groups, has provided a great degree of insight into the molecular mechanisms of actions of …
Contributions of transcriptional noise to leukaemia evolution: KAT2A as a case-study
C Pina - Philosophical Transactions of the Royal Society …, 2024 - royalsocietypublishing.org
Transcriptional noise is proposed to participate in cell fate changes, but contributions to
mammalian cell differentiation systems, including cancer, remain associative. Cancer …
mammalian cell differentiation systems, including cancer, remain associative. Cancer …
Long non-coding RNA ACTA2-AS1 promotes ductular reaction by interacting with the p300/ELK1 complex
Background & Aims Biliary disease is associated with a proliferative/fibrogenic ductular
reaction (DR). p300 is an epigenetic regulator that acetylates lysine 27 on histone 3 …
reaction (DR). p300 is an epigenetic regulator that acetylates lysine 27 on histone 3 …
Divergent functions of histone acetyltransferases KAT2A and KAT2B in keratinocyte self-renewal and differentiation
The mammalian epidermis undergoes constant renewal, replenished by a pool of stem cells
and terminal differentiation of their progeny. This is accompanied by changes in gene …
and terminal differentiation of their progeny. This is accompanied by changes in gene …
Transcriptional activation of MYC-induced genes by GCN5 promotes B-cell lymphomagenesis
Overexpression of the MYC oncoprotein is an initiating step in the formation of several
cancers. MYC frequently recruits chromatin-modifying complexes to DNA to amplify the …
cancers. MYC frequently recruits chromatin-modifying complexes to DNA to amplify the …
Epigenomic evaluation of cholangiocyte transforming growth factor-β signaling identifies a selective role for histone 3 lysine 9 acetylation in biliary fibrosis
SO Aseem, N Jalan-Sakrikar, C Chi… - Gastroenterology, 2021 - Elsevier
Background & Aims Transforming growth factor β (TGFβ) upregulates cholangiocyte-derived
signals that activate myofibroblasts and promote fibrosis. Using epigenomic and …
signals that activate myofibroblasts and promote fibrosis. Using epigenomic and …
[HTML][HTML] Repression of GCN5 expression or activity attenuates c-MYC expression in non-small cell lung cancer
Lung cancer causes the highest mortality in cancer-related deaths. As these cancers often
become resistant to existing therapies, definition of novel molecular targets is needed …
become resistant to existing therapies, definition of novel molecular targets is needed …
Histone acetyltransferase KAT2A stabilizes pluripotency with control of transcriptional heterogeneity
Cell fate transitions in mammalian stem cell systems have often been associated with
transcriptional heterogeneity; however, existing data have failed to establish a functional or …
transcriptional heterogeneity; however, existing data have failed to establish a functional or …
USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta
ABSTRACT USP22, a component of the SAGA complex, is overexpressed in highly
aggressive cancers, but the normal functions of this deubiquitinase are not well defined. We …
aggressive cancers, but the normal functions of this deubiquitinase are not well defined. We …
Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells
Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy with abnormal
progenitor self-renewal and defective white blood cell differentiation. Its pathogenesis …
progenitor self-renewal and defective white blood cell differentiation. Its pathogenesis …