Dynamic DNA methylation: In the right place at the right time
The classical model of cytosine DNA methylation (the presence of 5-methylcytosine, 5mC)
regulation depicts this covalent modification as a stable repressive regulator of promoter …
regulation depicts this covalent modification as a stable repressive regulator of promoter …
Genomic imprinting disorders: lessons on how genome, epigenome and environment interact
Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset
of genes, is required for normal development, and its disruption leads to human disease …
of genes, is required for normal development, and its disruption leads to human disease …
DNA methylation at the crossroads of gene and environment interactions
PP Law, ML Holland - Essays in biochemistry, 2019 - portlandpress.com
DNA methylation is an epigenetic mark involved in regulating genome function and is critical
for normal development in mammals. It has been observed that the developmental …
for normal development in mammals. It has been observed that the developmental …
Imprinted genes and the manipulation of parenting in mammals
Genomic imprinting refers to the parent-of-origin expression of genes, which originates from
epigenetic events in the mammalian germ line. The evolution of imprinting may reflect a …
epigenetic events in the mammalian germ line. The evolution of imprinting may reflect a …
Crosstalk of genetic variants, allele-specific DNA methylation, and environmental factors for complex disease risk
Over the past decades, genome-wide association studies (GWAS) have identified thousands
of phenotype-associated DNA sequence variants for potential explanations of inter …
of phenotype-associated DNA sequence variants for potential explanations of inter …
Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice
Transmission of epigenetic information between generations occurs in nematodes, flies and
plants, mediated by specialised small RNA pathways, modified histones and DNA …
plants, mediated by specialised small RNA pathways, modified histones and DNA …
Interventions designed to reduce excessive gestational weight gain can reduce the incidence of gestational diabetes mellitus: A systematic review and meta-analysis …
Aims To (i) evaluate the global impact of interventions designed to prevent excessive
gestational weight gain (eGWG) on the incidence of gestational diabetes (GDM), and (ii) …
gestational weight gain (eGWG) on the incidence of gestational diabetes (GDM), and (ii) …
Genomic imprinting and its effects on postnatal growth and adult metabolism
SJ Millership, M Van de Pette, DJ Withers - Cellular and Molecular Life …, 2019 - Springer
Imprinted genes display parent-of-origin-specific expression with this epigenetic system of
regulation found exclusively in therian mammals. Historically, defined imprinted gene …
regulation found exclusively in therian mammals. Historically, defined imprinted gene …
Developmental epigenetics: phenotype and the flexible epigenome
RM John, C Rougeulle - Frontiers in cell and developmental biology, 2018 - frontiersin.org
The term “epigenetics” has been widely used and abused (Greally, 2018) but the most
compelling definition of epigenetics is the study of changes in gene function that are …
compelling definition of epigenetics is the study of changes in gene function that are …
[HTML][HTML] Regulation of de novo and maintenance DNA methylation by DNA methyltransferases in postimplantation embryos
Z Xu, J Shi, Q Chen, S Yang, Z Wang, B Xiao… - Journal of Biological …, 2025 - Elsevier
DNA methylation is mainly catalyzed by three DNA methyltransferase (DNMT) proteins in
mammals. Usually DNMT1 is considered the primary DNMT for maintenance DNA …
mammals. Usually DNMT1 is considered the primary DNMT for maintenance DNA …