Hydrophobically tagged small molecules as inducers of protein degradation

N Gray, T Xie, SM Lim, PA Janne, CM Crews - US Patent 9,758,522, 2017 - Google Patents
Provided are bifunctional small molecules of Formula (I): or pharmaceutically acceptable
salts thereof, wherein M rep resents a small organic molecule which binds, covalently or non …

Trk-inhibiting compound

J Takeuchi, S Itadani, K Hashimura, M Ikura… - US Patent …, 2016 - Google Patents
Feb. 19, 2013 (JP)................................. 2013-O29563 Jul. 5, 2013 (JP)................................. 2013-
141246 (57) ABSTRACT The present invention provides a drug containing a com (51) Int …

Trk-inhibiting compound

J Takeuchi, M Ikura, M Higashino, M Iwahashi… - US Patent …, 2016 - Google Patents
2014-10-24 Assigned to ONO PHARMACEUTICAL CO., LTD. reassignment ONO
PHARMACEUTICAL CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE …

Type II Raf kinase inhibitors

NS Gray, HG Choi, X Deng, J Zhang - US Patent 9,180,127, 2015 - Google Patents
US9180127B2 - Type II Raf kinase inhibitors - Google Patents US9180127B2 - Type II Raf
kinase inhibitors - Google Patents Type II Raf kinase inhibitors Download PDF Info Publication …

Fused 2-aminothiazole compounds

HG Choi, T Sim, N Gray, W Zhou, JW Chang… - US Patent …, 2016 - Google Patents
(51) Int. Cl. Ben-Av et al., Induction of vascular endothelial growth factor CO7D
53/04(2006.01) expression in Synovial fibroblasts by prostaglandin E and A6 IK …

Compounds for inhibiting cell proliferation in EGFR-driven cancers

DC Dalgarno, WS Huang, WC Shakespeare… - US Patent …, 2017 - Google Patents
The invention features compounds, pharmaceutical compo sitions and methods for treating
patients who have an EGFR-driven cancer of formula I:(52) Int. Cl. C07D 239/46(2006. 01) …

Combination therapy of transcription inhibitors and kinase inhibitors

P Hammerman, K Wong, NS Gray - US Patent 10,702,527, 2020 - Google Patents
The present disclosure provides combination therapy of a transcription inhibitor and a
kinase inhibitor. The combination of the transcription inhibitor and the kinase inhibitor may …

Phosphorous derivatives as kinase inhibitors

Y Wang, WS Huang, S Liu, WC Shakespeare… - US Patent …, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
41340562&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Inhibitors of c-Jun-N-terminal kinase (JNK)

N Gray, T Zhang - US Patent 9,382,239, 2016 - Google Patents
2015-08-17 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof

N Gray, S Balk, Q Liu, S Chen - US Patent 10,000,483, 2018 - Google Patents
2014-06-27 Assigned to BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
reassignment BETH ISRAEL DEACONESS MEDICAL CENTER, INC. ASSIGNMENT OF …