Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

The identification of RNAs that are not translated into proteins was an important
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …

Neuroinflammation is proposed as one of the mechanisms by which Alzheimer's disease
pathology, including amyloid-β plaques, leads to neuronal death and dysfunction. Increases …

Mixed pathology, with both Alzheimer's disease and vascular abnormalities, is the most
common cause of clinical dementia in the elderly. While usually thought to be concurrent …

Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly
expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific …

Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …

Translating human genetic findings (genome-wide association studies [GWAS]) to
pathobiology and therapeutic discovery remains a major challenge for Alzheimer's disease …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the main cause
of dementia among the elderly worldwide. Despite intense efforts to develop drugs for …

Only a small fraction of the human genome corresponds to protein-coding genes.
Historically, the vast majority of genomic sequence was dismissed as transcriptionally silent …

The characteristic maximum lifespan varies enormously across animal species from a few
hours to hundreds of years. This argues that maximum lifespan, and the ageing process that …