The critical role of apoptosis in mesenchymal stromal cell therapeutics and implications in homeostasis and normal tissue repair

C Giacomini, C Granéli, R Hicks, F Dazzi - Cellular & Molecular …, 2023 - nature.com
Mesenchymal stromal cells (MSCs) have been extensively tested for the treatment of
numerous clinical conditions and have demonstrated good safety but mixed efficacy …

Angiogenesis in wound repair: too much of a good thing?

C Han, M Barakat, LA DiPietro - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
Angiogenesis, or the growth of new blood vessels from the preexisting vasculature, is a
visible and important component of wound repair. When tissue damage occurs, disruption of …

Understanding the phagocytosis of particles: the key for rational design of vaccines and therapeutics

S Moreno-Mendieta, D Guillén… - Pharmaceutical …, 2022 - Springer
A robust comprehension of phagocytosis is crucial for understanding its importance in innate
immunity. A detailed description of the molecular mechanisms that lead to the uptake and …

Tracing the evolutionary history of blood cells to the unicellular ancestor of animals

Y Nagahata, K Masuda, Y Nishimura… - Blood, The Journal …, 2022 - ashpublications.org
Blood cells are thought to have emerged as phagocytes in the common ancestor of animals
followed by the appearance of novel blood cell lineages such as thrombocytes, erythrocytes …

Polyphenol hydroxytyrosol present olive oil improves skin wound healing of diabetic mice

MS Duarte, VM Fuhro… - Wound Repair and …, 2024 - Wiley Online Library
The imbalance in oxidant production and chronic inflammation are the main mechanisms
that lead to the detrimental effects of diabetes on skin wound healing. Thus, administration of …

Apoptosis recognition receptors regulate skin tissue repair in mice

O Justynski, K Bridges, W Krause, MF Forni, QM Phan… - Elife, 2023 - elifesciences.org
Apoptosis and clearance of apoptotic cells via efferocytosis are evolutionarily conserved
processes that drive tissue repair. However, the mechanisms by which recognition and …

Modulation of cell behavior by 3D biocompatible hydrogel microscaffolds with precise configuration

WC Zhang, ML Zheng, J Liu, F Jin, XZ Dong, M Guo… - Nanomaterials, 2021 - mdpi.com
Three-dimensional (3D) micronano structures have attracted much attention in tissue
engineering since they can better simulate the microenvironment in vivo. Two-photon …

Microfibril-associated protein 5 and the regulation of skin scar formation

C Han, TR Leonardo, B Romana-Souza, J Shi… - Scientific reports, 2023 - nature.com
Many factors regulate scar formation, which yields a modified extracellular matrix (ECM).
Among ECM components, microfibril-associated proteins have been minimally explored in …

[HTML][HTML] Modulation of IFN-γ induced macrophage inflammatory responses via indomethacin-loaded NLCs for OA management

R Martínez-Borrajo, H Rouco, NF Virzì… - International Journal of …, 2024 - Elsevier
Macrophages are the main cells present in the synovial membrane. They play an important
role in the development and progression of osteoarthritis (OA). After the establishment of the …

Inflammation and Macrophage Loss Mark Increased Susceptibility in a Genetic Model of Acute Viral Infection–Induced Tissue Damage

JL Annis, MG Brown - The Journal of Immunology, 2024 - journals.aai.org
M. R2 k/b mice are identical to the MA/My parent strain aside from a 5.58-Mb C57L-derived
region on chromosome 17 (Cmv5 s) that causes increased susceptibility to acute murine …