NFE2-like basic leucine zipper transcription factor 2 (NFE2L2, also known as NRF2), is a
key transcription factor in the cellular defense against oxidative stress, playing a crucial role …

In tumors, the rapid proliferation of cells and the imperfect blood supply system lead to
hypoxia, which can regulate the adaptation of tumor cells to the hypoxic environment …

Metastatic dissemination to distant organs demands that cancer cells possess high
morphological and metabolic adaptability. However, contributions of the cellular lipidome to …

Ferroptosis is an iron-dependent lipid peroxidation-mediated cell death. It is distinct from
other types of cellular death and is recognized as a potential target for cancer therapy. This …

Emerging evidence suggests that cancer cells may disseminate early, prior to the formation
of traditional macro-metastases. However, the mechanisms underlying the seeding and …

Elevated lipid metabolism is one of hallmarks of malignant tumors. Lipids not only serve as
essential structural components of biological membranes but also provide energy and …

As a novel form of nonapoptotic cell death, ferroptosis is developing into a promising
therapeutic target of dedifferentiating and therapy-refractory cancers. However, its …

Cancer cells exhibit a remarkable ability to orchestrate metabolic adaptations to survive and
proliferate. Such metabolic adaptations, including carbohydrates, amino acids and lipid …

Ferroptosis, a form of iron-dependent cell death driven by lipid peroxidation, has emerged
as a critical area of research for cancer therapy. This review delves into the intricate …

Lung ischemia-reperfusion injury (IRI), a common complication after lung transplantation
(LTx), plays a crucial role in both primary graft dysfunction (PGD) and chronic lung allograft …