Cell cycle errors can lead to mutations, chromosomal instability, or death; thus, the precise
control of cell cycle progression is essential for viability. The nutrient-sensing post …

Abstract O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a dynamic and reversible
posttranslational modification that targets serine and threonine residues in a variety of …

The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell
growth, metabolism and autophagy. Multiple pathways modulate mTORC1 in response to …

O-linked N-acetylglucosamine protein modification (O-GlcNAcylation) is a dynamic post-
translational modification (PTM) involving the covalent binding of serine and/or threonine …

Metabolic homeostasis and the ability to link energy supply to demand are essential
requirements for all living cells to grow and proliferate. Key to metabolic homeostasis in all …

Metabolic changes are coupled with alteration in protein glycosylation. In this review, we will
focus on macrophages that are pivotal in the pathogenesis of pulmonary fibrosis and …

Abstract Sodium-glucose co-transporter 2 (SGLT2) inhibitor (SGLT2i) is a novel class of anti-
diabetic drug, which has displayed a promising benefit for non-alcoholic fatty liver disease …

O-Linked β-N-acetylglucosamine (O-GlcNAc) is an essential, dynamic monosaccharide post-
translational modification (PTM) found on serine and threonine residues of thousands of …

The reversible glycosylation of nuclear and cytoplasmic proteins (O-GlcNAcylation) is
catalyzed by a single enzyme, namely O-GlcNAc transferase (OGT). The mammalian Ogt …

A sweet way to regulate cellular growth: OGT and mTOR join forces Page 1 Previews A
sweet way to regulate cellular growth: OGT and mTOR join forces Pedro Latorre-Muro1,2 …