Developments of pyridodipyrimidine heterocycles and their biological activities
The entitled review aimed to assemble and highlight the synthetic approaches and
biological aspects of heterocycles with pyridodipyrimidine motifs. The recent synthetic …
biological aspects of heterocycles with pyridodipyrimidine motifs. The recent synthetic …
Design, synthesis, DFT, TD-DFT/PCM calculations, and molecular docking studies on the anti-COVID-19, and anti-SARS activities of some new bis-thiazoles and bis …
A novel synthesis of bis (thiazoles) and bis (thiadiazole), each connected to a
thienothiophene moiety, is described. The DFT calculations support the favored synthesis of …
thienothiophene moiety, is described. The DFT calculations support the favored synthesis of …
New thiazole and thiazole-chromene hybrids possessing morpholine units: Piperazine-mediated one-pot synthesis of potential acetylcholinesterase inhibitors
In the current study, new morpholine-linked thiazoles were prepared by the reaction of
salicylaldehyde derivative, thiosemicarbazide, and α-bromoketones. To mediate the …
salicylaldehyde derivative, thiosemicarbazide, and α-bromoketones. To mediate the …
3‐Aminopyrazolo[3,4‐b]pyridine: Effective Precursor for Barium Hydroxide‐Mediated Three Components Synthesis of New Mono‐ and Bis(pyrimidines) with Potential …
In this study, an efficient one‐pot procedure for preparing a new series of pyrazolo [3, 4‐b]
pyridine‐fused pyrimidines was described. The target hybrids were developed through a …
pyridine‐fused pyrimidines was described. The target hybrids were developed through a …
Bis-aldehydes: Versatile precursors for bis-heterocycles
IA Abdelhamid, MR Shaaban, AHM Elwahy - Advances in Heterocyclic …, 2023 - Elsevier
The widest variety of organic molecules, with major uses in industry, biomedicine, and
chemistry, are heterocycles. They can be found as scaffolds in several medications and …
chemistry, are heterocycles. They can be found as scaffolds in several medications and …
Hantzsch‐like synthesis, DNA photocleavage, DNA/BSA binding, and molecular docking studies of bis (sulfanediyl) bis (tetrahydro‐5‐deazaflavin) analogs linked to …
MA Ragheb, RE Abdelwahab… - Chemistry & …, 2022 - Wiley Online Library
The cyclocondensation reaction of aldehydes with dimedone and bis (6‐aminopyrimidin‐4‐
one) in acetic acid led to the formation of the corresponding bis (pyrimido [4, 5‐b] quinoline …
one) in acetic acid led to the formation of the corresponding bis (pyrimido [4, 5‐b] quinoline …
New pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one hybrids linked to arene units: synthesis of potential MRSA, VRE, and COX-2 inhibitors
In the current study, we reported the tandem synthesis of two series of arene-linked
pyrimidinone hybrids with related fused thieno [2, 3-b] pyridine moiety. The target hybrids …
pyrimidinone hybrids with related fused thieno [2, 3-b] pyridine moiety. The target hybrids …
Effective synthesis of new benzo-fused macrocyclic and heteromacrocyclic bis (Schiff bases)
In this study, the synthons 2-hydroxy-5-((arylthio) methyl) benzaldehydes were reacted with
1, ω-dihaloalkanes to produce the corresponding bis (aldehydes). The previous precursors …
1, ω-dihaloalkanes to produce the corresponding bis (aldehydes). The previous precursors …
Hantzsch-like synthesis of bis(sulfanediyl)bis(tetrahydropyrimido[4,5-b]quinoline-4,6-diones) linked to arene or heteroarene cores utilizing bis(sulfanediyl)bis(6 …
A novel series of bis (sulfanediyl) bis (tetrahydropyrimido [4, 5-b] quinoline-4, 6-diones)
which are linked to benzene, pyridine, or thieno [4, 5-d] thiophene cores were prepared to …
which are linked to benzene, pyridine, or thieno [4, 5-d] thiophene cores were prepared to …
Six-membered ring systems: pyridines and benzo derivatives
JC Badenock - Progress in Heterocyclic Chemistry, 2023 - Elsevier
The class of pyridines and their benzo derivatives maintain prominence in the synthetic
literature due to their versatility and chemical and biological properties. These scaffolds …
literature due to their versatility and chemical and biological properties. These scaffolds …