PLGA/PLA-based long-acting injectable depot microspheres in clinical use: production and characterization overview for protein/peptide delivery

A Butreddy, RP Gaddam, N Kommineni… - International journal of …, 2021 - mdpi.com
Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide
(PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled …

Long-acting PLGA microspheres: advances in excipient and product analysis toward improved product understanding

B Wan, Q Bao, D Burgess - Advanced drug delivery reviews, 2023 - Elsevier
Poly (lactic-co-glycolic acid)(PLGA) microspheres are a sustained-release drug delivery
system with several successful commercial products used for the treatment of a variety of …

FDA's poly (lactic-co-glycolic acid) research program and regulatory outcomes

Y Wang, B Qin, G Xia, SH Choi - The AAPS Journal, 2021 - Springer
Poly (lactic-co-glycolic acid)(PLGA) has been used in many long-acting drug formulations
which have been approved by the US Food and Drug Administration (FDA). However …

Polyester based polymeric nano and microparticles for pharmaceutical purposes: A review on formulation approaches

F Molavi, M Barzegar-Jalali, H Hamishehkar - Journal of Controlled …, 2020 - Elsevier
The novel polymeric particulate systems show high potential in their clinical effectiveness.
Nevertheless, many of the drug delivery systems developed in the research laboratories …

Challenges and Complications of Poly(lactic-co-glycolic acid)-Based Long-Acting Drug Product Development

YW Lim, WS Tan, KL Ho, AR Mariatulqabtiah… - Pharmaceutics, 2022 - mdpi.com
Poly (lactic-co-glycolic acid)(PLGA) is one of the preferred polymeric inactive ingredients for
long-acting parenteral drug products that are constituted of complex formulations. Despite …

Catechol functionalized chitosan/active peptide microsphere hydrogel for skin wound healing

D Zhang, Q Ouyang, Z Hu, S Lu, W Quan, P Li… - International Journal of …, 2021 - Elsevier
Chitosan-based thermosensitive hydrogels have been widely used in drug delivery and
tissue engineering, but their poor bioactivity has limited their further applications. Integral …

Current trends in PLGA based long-acting injectable products: The industry perspective

OS Muddineti, A Omri - Expert Opinion on Drug Delivery, 2022 - Taylor & Francis
Introduction Poly (lactic-co-glycolic acid)(PLGA) has been used in many long-acting drug
formulations, which have been approved by the US Food and Drug Administration (FDA) …

Patient-centric long-acting injectable and implantable platforms─ an industrial perspective

S Alidori, R Subramanian, R Holm - Molecular pharmaceutics, 2024 - ACS Publications
The increasing focus on patient centricity in the pharmaceutical industry over the past
decade and the changing healthcare landscape, driven by factors such as increased access …

State-of-the-art review of artificial neural networks to predict, characterize and optimize pharmaceutical formulation

S Wang, J Di, D Wang, X Dai, Y Hua, X Gao, A Zheng… - Pharmaceutics, 2022 - mdpi.com
During the development of a pharmaceutical formulation, a powerful tool is needed to extract
the key points from the complicated process parameters and material attributes. Artificial …

Recent progress in drug release testing methods of biopolymeric particulate system

Y Kim, EJ Park, TW Kim, DH Na - Pharmaceutics, 2021 - mdpi.com
Biopolymeric microparticles have been widely used for long-term release formulations of
short half-life chemicals or synthetic peptides. Characterization of the drug release from …