Application of designed enzymes in organic synthesis

GA Strohmeier, H Pichler, O May… - Chemical …, 2011 - ACS Publications
Catalysis is a key discipline in chemistry enabling clean and cost-efficient processes for a
large variety of different products and, therefore, has a strong economic impact in industry …

Protein engineering of microbial enzymes

D Böttcher, UT Bornscheuer - Current opinion in microbiology, 2010 - Elsevier
Protein engineering has emerged as an important tool to overcome the limitations of natural
enzymes as biocatalysts. Recent advances have mainly focused on applying directed …

Chemo‐biological upcycling of poly (ethylene terephthalate) to multifunctional coating materials

HT Kim, M Hee Ryu, YJ Jung, S Lim, HM Song… - …, 2021 - Wiley Online Library
Chemo‐biological upcycling of poly (ethylene terephthalate)(PET) developed in this study
includes the following key steps: chemo‐enzymatic PET depolymerization, biotransformation …

Discovery and protein engineering of biocatalysts for organic synthesis

GA Behrens, A Hummel, SK Padhi… - Advanced Synthesis …, 2011 - Wiley Online Library
Modern tools for enzyme discovery and protein engineering substantially broadened the
number of enzymes applicable for biocatalysis and helped to alter their properties such as …

Esterases as stereoselective biocatalysts

D Romano, F Bonomi, MC de Mattos… - Biotechnology …, 2015 - Elsevier
Non-lypolitic esterases are carboxylester hydrolases with preference for the hydrolysis of
water-soluble esters bearing short-chain acyl residues. The potential of esterases as …

Enzymatic synthesis of optically active tertiary alcohols: expanding the biocatalysis toolbox

R Kourist, P Dominguez de Maria… - …, 2008 - Wiley Online Library
Enantiopure tertiary alcohols are very valuable building blocks for the synthesis of many
different natural products and pharmaceuticals. As a consequence, several chemical and …

Gerichtete Evolution stereoselektiver Enzyme: Eine ergiebige Katalysator‐Quelle für asymmetrische Reaktionen

MT Reetz - Angewandte Chemie, 2011 - Wiley Online Library
Abstract Asymmetrische Katalyse spielt eine Schlüsselrolle in der modernen synthetischen
organischen Chemie, wobei künstliche Katalysatoren und Enzyme die zwei wichtigsten …

Biocatalytic synthesis of optically active tertiary alcohols

R Kourist, UT Bornscheuer - Applied microbiology and biotechnology, 2011 - Springer
The enzymatic preparation of optically pure tertiary alcohols under sustainable conditions
has received much attention. The conventional chemical synthesis of these valuable …

Catalytic Enantioselective Alkynylation of Trifluoromethyl Ketones: Pronounced Metal Fluoride Effects and Implications of Zinc‐to‐Titanium Transmetallation

GW Zhang, W Meng, H Ma, J Nie, WQ Zhang… - Angewandte Chemie, 2011 - infona.pl
Einflussreich: Die Titan (IV)‐katalysierte Titelreaktion mit chiralen Cinchona‐Alkaloiden als
Liganden (L1 und L2) ermöglicht die Synthese beider Enantiomere von trifluormethylierten …

Phage-assisted continuous evolution and selection of enzymes for chemical synthesis

KA Jones, HM Snodgrass, K Belsare… - ACS Central …, 2021 - ACS Publications
Ligand-dependent biosensors are valuable tools for coupling the intracellular
concentrations of small molecules to easily detectable readouts such as absorbance …