Background The prognostic relevance of isolated tumor cells and micrometastases in lymph
nodes from patients with breast cancer has become a major issue since the introduction of …

BACKGROUND The presence or absence of regional lymph node metastases has been one
of the most important determining factors in recommending adjuvant chemotherapy for …

Purpose To develop a guideline for the use of sentinel node biopsy (SNB) in early stage
breast cancer. Methods An American Society of Clinical Oncology (ASCO) Expert Panel …

Telomeres are DNA-protein structures that cap linear chromosomes and are essential for
maintaining genomic stability and cell phenotype. We identified a novel human telomere …

Context Immunochemical staining of sentinel lymph nodes (SLNs) and bone marrow
identifies breast cancer metastases not seen with routine pathological or clinical …

Methods From February 1994 through October 1995, patients with breast cancer were
staged with sentinel lymphadenectomy followed by completion level I and II axillary …

Background This study was designed to ascertain whether immunohistochemical methods
could improve the detection of metastases in primary breast cancer patients whose axillary …

Objective: To describe the magnitude of changes and opportunities that may arise for
simplified surgical procedures for women with breast cancer because of the decreasing size …

Cyclin-dependent kinases (CDKs) are activated by CDC25 phosphatases, which remove
inhibitory phosphate from tyrosine and threonine residues. In human cells, CDC25 proteins …

Background: Axillary lymph node status is the strongest prognostic indicator of survival for
women with breast cancer. The purpose of this study was to determine the incidence of …