Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Highlights•The most accurate complex models are built by copying close homologous
templates.•Non-homologous templates can be detected by interface structure comparisons.• …

Abstract Background Protein-protein interactions (PPIs) are central to many biological
processes. Considering that the experimental methods for identifying PPIs are time …

Background Drug-target networks are receiving a lot of attention in late years, given its
relevance for pharmaceutical innovation and drug lead discovery. Different in silico …

Protein interactions play an important role in the discovery of protein functions and pathways
in biological processes. This is especially true in case of the diseases caused by the loss of …

Protein–protein interactions are closely relevant to protein function and drug discovery.
Hence, accurately identifying protein–protein interactions will help us to understand the …

Protein-protein interactions (PPIs) play a critical role in the proteomics study, and a variety of
computational algorithms have been developed to predict PPIs. Though effective, their …

Background Although homology-based methods are among the most widely used methods
for predicting the structure and function of proteins, the question as to whether interface …

High-throughput interaction discovery initiatives have revealed the existence of hundreds of
multiprotein complexes whose functions are regulated through thousands of protein–protein …

The elucidation of protein-protein interaction (PPI) networks is important for understanding
cellular structure and function and structure-based drug design. However, the development …