Chronic exposure to excess glucorticoids results in diverse manifestations of Cushing's
syndrome, including debilitating morbidities and increased mortality. Genetic and molecular …

Cushing's syndrome results from lengthy and inappropriate exposure to excessive
glucocorticoids. Untreated, it has significant morbidity and mortality. The syndrome remains …

Patients with primary bilateral macronodular adrenal hyperplasia (PBMAH) usually present
bilateral benign adrenocortical macronodules at imaging and variable levels of cortisol …

Diagnosis and Differential Diagnosis of Cushing’s Syndrome and Pseudo-Cushing’s States |
Endocrine Reviews | Oxford Academic Skip to Main Content Advertisement Oxford Academic …

OVER the past few years, considerable evidence has accumulated to challenge the
accepted view of the regulation of adrenocortical function. Conventionally, the cortex and …

Context: Subclinical hypercortisolism (SH) is a condition of biochemical cortisol excess
without the classical signs or symptoms of overt hypercortisolism. It is thought to be present …

Background Bilateral macronodular adrenal hyperplasia is a rare cause of primary adrenal
Cushing's syndrome. In this form of hyperplasia, hypersecretion of cortisol suppresses the …

The mechanism by which cortisol is produced in adrenal Cushing's syndrome, when ACTH
is suppressed, was previously unknown and was referred to as being “autonomous.” More …

Background GIP-dependent primary bilateral macronodular adrenal hyperplasia with
Cushing's syndrome is caused by aberrant expression of the GIP receptor in adrenal …

Primary bilateral macronodular adrenal hyperplasia (PBMAH) is an adrenal cause of
Cushing syndrome. Nowadays, a PBMAH diagnosis is more frequent than previously, as a …