The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …

The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-
related deaths. Yet, it remains poorly understood. The continuous evolution of cancer …

Prostate cancer (PCa) is one of the most prevalent malignancies in adult males. However,
PCa is resistant to multi-kinase inhibitors-based anti-angiogenic therapies, and the …

Cancer stem cells (CSCs) are a distinct population of cells within tumors with capabilities of
self-renewal and tumorigenicity. CSCs play a pivotal role in cancer progression, metastasis …

Cancer is a multifaceted and complex pathology characterized by uncontrolled cell
proliferation and decreased apoptosis. Most cancers are recognized by an inflammatory …

Osteosarcoma (OS) is the most common primary bone malignancy and responsible for
considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although …

Cancer stem cells, a relatively small group of self-renewing cancer cells, were first isolated
from acute myeloid leukemia. These cells can play a crucial role in tumor metastasis …