Hyperhomocysteinemia: impact on neurodegenerative diseases
Neurodegenerative diseases are the diseases of the central nervous system with various
aetiology and symptoms. Dementia, Alzheimer's disease (AD), Parkinson's disease (PD) …
aetiology and symptoms. Dementia, Alzheimer's disease (AD), Parkinson's disease (PD) …
The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects
F Coppedè - Frontiers in genetics, 2015 - frontiersin.org
Almost 15 years ago it was hypothesized that polymorphisms of genes encoding enzymes
involved in folate metabolism could lead to aberrant methylation of peri-centromeric regions …
involved in folate metabolism could lead to aberrant methylation of peri-centromeric regions …
L-DOPA-induced hyperhomocysteinemia in Parkinson's disease: elephant in the room
R Paul, A Borah - Biochimica et Biophysica Acta (BBA)-General Subjects, 2016 - Elsevier
Background Dopamine replacement therapy by its precursor, L-3.4-dihydroxyphenylalanine
(L-DOPA), has been the treatment of choice for Parkinson's disease. However, the possible …
(L-DOPA), has been the treatment of choice for Parkinson's disease. However, the possible …
Analysis of association between components of the folate metabolic pathway and autism spectrum disorder in eastern Indian subjects
Background Folate has a pivotal role in maintaining different cellular processes including
DNA integrity and neurotransmitter levels. Further, folate deficiency was reported in subjects …
DNA integrity and neurotransmitter levels. Further, folate deficiency was reported in subjects …
Synthetic combinations of missense polymorphic genetic changes underlying Down syndrome susceptibility
RA Jackson, ML Nguyen, AN Barrett, YY Tan… - Cellular and molecular …, 2016 - Springer
Single nucleotide polymorphisms (SNPs) are important biomolecular markers in health and
disease. Down syndrome, or Trisomy 21, is the most frequently occurring chromosomal …
disease. Down syndrome, or Trisomy 21, is the most frequently occurring chromosomal …
BHMT G742A and MTHFD1 G1958A Polymorphisms and Down Syndrome Risk in the Brazilian Population
Background: Mechanisms underlying meiotic nondisjunction are poorly understood.
Attempts to elucidate the causes of Down syndrome (DS) have analyzed the relationship …
Attempts to elucidate the causes of Down syndrome (DS) have analyzed the relationship …
One-carbon metabolism and global DNA methylation in mothers of individuals with Down syndrome
CC Mendes, BL Zampieri, LMRB Arantes… - Human cell, 2021 - Springer
Down syndrome (DS) is the most common chromosomal disorder, resulting from the failure
of normal chromosome 21 segregation. Studies have suggested that impairments within the …
of normal chromosome 21 segregation. Studies have suggested that impairments within the …
Differential effect of folate metabolic system genetic variants on attention deficit hyperactivity disorder severity
Background Adequate folate level is vital for the synthesis of neurotransmitters, and hence,
folate deficiency was related to neurobehavioral disorders like depression, Autism spectrum …
folate deficiency was related to neurobehavioral disorders like depression, Autism spectrum …
Association between polymorphisms in folate metabolism genes and maternal risk for Down syndrome: A meta‑analysis
Y Gu - Molecular and Clinical Oncology, 2017 - spandidos-publications.com
Previous studies have focused on the association between polymorphisms of the genes
involved in folate metabolism and Down syndrome (DS); however, the results remain …
involved in folate metabolism and Down syndrome (DS); however, the results remain …
DHFR 19-bp Deletion and SHMT C1420T Polymorphisms and Metabolite Concentrations of the Folate Pathway in Individuals with Down Syndrome
CC Mendes, AMZA Raimundo, LD Oliveira… - Genetic testing and …, 2013 - liebertpub.com
Background: Down syndrome (DS) results from the presence and expression of three copies
of the genes located on chromosome 21. Studies have shown that, in addition to …
of the genes located on chromosome 21. Studies have shown that, in addition to …