Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission
and are implicated in various neurological disorders. In this review, we discuss the role of …

Despite extensive research in recent decades, knowledge of the pathophysiology of
depression in neural circuits remains limited. Recently, the lateral habenula (LHb) has been …

The anteroventral bed nucleus of the stria terminalis (avBNST) is widely acknowledged as a
key brain structure that regulates negative emotional states, such as anxiety. At present, it is …

Recent studies show that neuron-glial communication plays an important role in
neurological diseases. Particularly, dysfunction of astroglial glutamate transporter GLT-1 has …

The hyperactivity of the lateral habenula (LHb) is closely associated with depression. At
present, it is unknown how GABA transporter (GAT) in the LHb affects depressive-like …

Increasing evidence indicates that dysfunction of glutamate receptors is involved in the
pathophysiology of major depressive disorder (MDD). Although accumulating efforts have …

Although the output of the lateral habenula (LHb) controls the activity of midbrain
dopaminergic and serotonergic systems, which are implicated in the pathophysiology of …

Although multiple studies report that unilateral 6-hydroxydopamine lesions of the substantia
nigra pars compacta (SNc) in rats induce depressive-like behaviors and hyperactivity of the …

Objective The aim of the present study was to investigate whether serotonin1B (5-HT1B)
receptor-adenylate cyclase (AC)-protein kinase A (PKA) signal pathway in the lateral …

Background: Parkinson's disease (PD) is commonly accompanied with anxiety disorder,
however, the mechanisms underlying PD-mediated anxiety remain elusive. The lateral …