For more than two decades, the view of the roles of non-coding RNAs (ncRNAs) has been
radically changing. These RNA molecules that are transcribed from our genome do not have …

Lung squamous cell carcinoma (LSCC) is a devastating malignancy with no effective
treatments, due to its complex genomic profile. Therefore, preclinical models mimicking its …

Squamous cell carcinoma (SCC) of the lung is the second most common subtype of lung
cancer. With limited treatment options, the 5-year survival rate of SCC is only 15%. Although …

Introduction: Squamous cell lung cancer (SQCLC) is the second most common subtype of
non-small cell lung cancer (NSCLC) and has limited therapeutic options. Its development is …

Phosphatidylinositol 3′-OH kinase (PI3K)-Akt and transcription factor NF-κB are important
molecules involved in the regulation of cell proliferation, apoptosis, and oncogenesis. Both …

Objective To investigate the clinicopathological significance of NF-κB p65 and IKKβ protein
and mRNA expression in nasopharyngeal carcinoma (NPC) patients from Guangdong …

Mouse models have informed us that p63 is critical for normal epidermal development and
homeostasis. The p53/p63/p73 family is expressed as multiple protein isoforms due to a …

IκB kinases (IKKs), specifically IKKα and IKKβ, have long been recognized for their pivotal
role in the NF-κB pathway, orchestrating immune and inflammatory responses. However …

Recent studies have shown that IκB kinase α (IKKα) plays an important role in human skin
cancer and acts as a major regulator for keratinocyte terminal differentiation and …

Background: Till today cancer is still challenging to treat and needs more active therapeutic
approaches. Participation of complex multi-pathway cell propagation instrument is a …