Specialized membrane domains are an important feature of almost all cells. In particular,
they are essential to tissues that have a highly organized cell cortex, such as the intestinal …

From an evolutionary perspective keratan sulfate (KS) is the newest glycosaminoglycan
(GAG) but the least understood. KS is a sophisticated molecule with a diverse structure, and …

Mucin domains are densely O-glycosylated modular protein domains that are found in a
wide variety of cell surface and secreted proteins. Mucin-domain glycoproteins are known to …

Podocalyxin, a sialomucin most closely related to CD34 and endoglycan, is expressed by
kidney podocytes, hematopoietic progenitors, vascular endothelia, and a subset of neurons; …

Micro RNAs are small non-coding RNAs, which regulate fundamental cellular and
developmental processes at the transcriptional and translational level. In breast cancer, miR …

An emerging point of view in protein chemistry is that proteins are not the static objects that
are displayed in textbooks but are instead dynamic actors. Protein dynamics plays a …

Cancer arises when pathways that control cell functions such as proliferation and migration
are dysregulated to such an extent that cells start to divide uncontrollably and eventually …

We screened for surface proteins expressed only by the early progenitor cells present in low-
passage, low-density cultures of the adult stem/progenitor cells from bone marrow referred …

The cell surface proteome, the surfaceome, is the interface for engaging the extracellular
space in normal and cancer cells. Here we apply quantitative proteomics of N-linked …

Cancer metastasis is the primary cause of morbidity and mortality in cancer as it remains the
most complicated, devastating, and enigmatic aspect of cancer. Several decades of …