Polygenic risk scores (PRSs) aggregate the many small effects of alleles across the human
genome to estimate the risk of a disease or disease-related trait for an individual. The …

The incidence of celiac disease is increasing, partly because of improved recognition of, and
testing for, the disease. The rise in incidence is also due to a real increase of this immune …

The innate immune system is the oldest protection strategy that is conserved across all
organisms. Although having an unspecific action, it is the first and fastest defense …

Abstract Knowledge of genetics and its implications for human health is rapidly evolving in
accordance with recent events, such as discoveries of large numbers of disease …

Background The relationship between the risk of celiac disease and both the age at which
gluten is introduced to a child's diet and a child's early dietary pattern is unclear. Methods …

The consumption of gluten-free products is becoming an increased alimentary habit in the
general population. The scientific unfounded perception suggesting that the avoidance of …

Purpose There is a critical need for population-based prospective cohort studies because
they follow individuals before the onset of disease, allowing for studies that can identify …

Objective Intestinal dysbiosis has been associated with coeliac disease (CD), but whether
the alterations are cause or consequence of the disease is unknown. This study investigated …

In the last 10,000 years, wheat has become one of the most important cereals in the human
diet and today, it is widely consumed in many processed food products. Mostly considered a …

Coeliac disease is a treatable, gluten-induced disease that often occurs concurrently with
other autoimmune diseases. In genetic studies since 2007, a partial genetic overlap …