Traditional therapeutic approaches such as chemotherapy and radiation therapy have
burdened cancer patients with onerous physical and psychological challenges …

Innate immunity is the first response to protect against pathogens and cellular insults.
Pattern recognition receptors sense pathogen-and damage-associated molecular patterns …

Lung-infiltrating macrophages create a marked inflammatory milieu in a subset of patients
with COVID-19 by producing a cytokine storm, which correlates with increased lethality …

Pyroptosis, apoptosis, necroptosis, and ferroptosis, which are the most well-studied
regulated cell death (RCD) pathways, contribute to the clearance of infected or potentially …

Nucleic acid sensing is a central process in the immune system, with far-reaching roles in
antiviral defense, autoinflammation, and cancer. Z-DNA binding protein 1 (ZBP1) is a sensor …

Regulated cell death (RCD) triggered by innate immune activation is an important strategy
for host survival during pathogen invasion and perturbations of cellular homeostasis. There …

Virus-induced cell death is a key contributor to COVID-19 pathology. Cell death induced by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is well studied in myeloid …

PANoptosis, a new research hotspot at the moment, is a cell death pattern in which
pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence …

The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …

The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2.
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …