Diagnosis and therapeutic management of liver fibrosis by MicroRNA

T Tadokoro, A Morishita, T Masaki - International Journal of Molecular …, 2021 - mdpi.com
Remarkable progress has been made in the treatment and control of hepatitis B and C viral
infections. However, fundamental treatments for diseases in which liver fibrosis is a key …

The roles of microRNAs in regulating the expression of PD-1/PD-L1 immune checkpoint

Q Wang, W Lin, X Tang, S Li, L Guo, Y Lin… - International journal of …, 2017 - mdpi.com
Engagement of programmed death-ligand 1 (PD-L1) with its receptor programmed death 1
(PD-1) on T cells has been speculated to play a major role in suppressing the immune …

Primary biliary cholangitis: A tale of epigenetically-induced secretory failure?

PM Rodrigues, MJ Perugorria, A Santos-Laso… - Journal of …, 2018 - Elsevier
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease associated with
autoimmune-related destruction of small to medium size intrahepatic bile ducts. The …

[HTML][HTML] MicroRNAs and extracellular vesicles in cholangiopathies

P Olaizola, PY Lee-Law, A Arbelaiz, A Lapitz… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Cholangiopathies encompass a heterogeneous group of disorders affecting biliary epithelial
cells (ie cholangiocytes). Early diagnosis, prognosis and treatment still remain clinically …

Plasma Extracellular Vesicles Enhance HIV-1 Infection of Activated CD4+ T Cells and Promote the Activation of Latently Infected J-Lat10.6 Cells via miR-139-5p …

I Okoye, L Xu, O Oyegbami, S Shahbaz, D Pink… - Frontiers in …, 2021 - frontiersin.org
HIV latency is a challenge to the success of antiretroviral therapy (ART). Hence patients may
benefit from interventions that efficiently reactivate the latent virus to be eliminated by ARTs …

Role of bile acids and the biliary HCO3− umbrella in the pathogenesis of primary biliary cholangitis

J van Niekerk, R Kersten, U Beuers - Clinics in liver disease, 2018 - liver.theclinics.com
The pathogenesis of primary biliary cholangitis (PBC), but also other chronic fibrosing
cholangiopathies, remains incompletely understood. 1 In search of a possible …

LncRNA NEAT1 promotes airway smooth muscle cell inflammation by activating the JAK3/STAT5 pathway through targeting of miR-139

MX Zhu, LH Huang, YK Zhu, XJ Cai - Experimental Lung Research, 2021 - Taylor & Francis
Background Asthma is a chronic inflammatory heterogeneous respiratory disease. Previous
studies showed that the lncRNA NEAT1 (nuclear paraspeckle assembly transcript 1) might …

miR-139-5p sponged by LncRNA NEAT1 regulates liver fibrosis via targeting β-catenin/SOX9/TGF-β1 pathway

Q Wang, S Wei, L Li, Q Bu, H Zhou, W Su, Z Liu… - Cell Death …, 2021 - nature.com
Liver fibrosis is a patho-physiological process which can develop into cirrhosis, and hepatic
carcinoma without intervention. Our study extensively investigated the mechanisms of …

Biomarkers for primary biliary cholangitis: current perspectives

E Kouroumalis, D Samonakis… - … Medicine: Evidence and …, 2018 - Taylor & Francis
Primary biliary cholangitis (PBC) is a chronic progressive cholestatic disease characterized
by destruction of small-and medium-sized intrahepatic bile ducts. It is no longer a rare …

Laser capture microdissection: techniques and applications in liver diseases

B Aguilar-Bravo, P Sancho-Bru - Hepatology International, 2019 - Springer
Routine transcriptomic and proteomic analysis are usually performed at a whole organ or
tissue level. These approaches provide an average readout of all cell types present within …