Lupus nephritis (LN) is a form of glomerulonephritis that constitutes one of the most severe
organ manifestations of the autoimmune disease systemic lupus erythematosus (SLE). Most …

Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

The autoimmune diseases are associated with the host immune system, chronic
inflammation, and immune reaction against self-antigens, which leads to the injury and …

Systemic lupus erythematosus (SLE) is a complex and heterogeneous systemic
autoimmune disease associated with innate and adaptive immune dysregulation. SLE …

This randomized, double‐blind, single‐and multiple‐ascending dose study assessed the
pharmacokinetics (PKs), pharmacodynamics, and safety of deucravacitinib (Sotyktu™), a …

While first and foremost considered a respiratory infection, COVID-19 can result in
complications affecting multiple organs. Immune responses in COVID-19 can both protect …

Metabolic syndrome (MetS) is a cluster of metabolic and cardiovascular (CV) risk factors
including obesity and visceral adiposity, insulin resistance, dyslipidemia and hypertension …

DNA sensing and timely activation of interferon (IFN)-mediated innate immunity are crucial
for the defense against DNA virus infections and the clearance of abnormal cells. However …

Immunomodulation is on the cusp of being an important therapy for treating many diseases,
due to the significant role of the immune system in defending the human body. Although the …

Psoriasis is an incurable, chronic inflammatory disease, which brings a substantial burden
on individuals and society. Currently, the treatment of psoriasis has entered the era of …