Abstract C1 inhibitor (C1Inh) deficiency is responsible for hereditary angioedema (C1‐INH‐
HAE) and caused by variants of the SERPING1/C1INH/C1NH gene. C1Inh is the major …

Contemporary genetic research has provided evidences that angioedema represents a
diverse family of disorders related to kinin metabolism, with a much greater genetic …

Hereditary angioedema with C1 Inhibitor deficiency (C1-INH-HAE) is caused by a
constellation of variants of the SERPING1 gene (n= 809; 1,494 pedigrees), accounting for …

The evolution in the knowledge of rare genetic diseases such as hereditary angioedema
(HAE) has increased at a parallel pace with the development of new molecular tools. The …

The plasma contact system contributes to thrombosis in experimental models. Even though
our standard blood coagulation tests are prolonged when plasma lacks contact factors, this …

Due to marked heterogeneity of clinical presentations, comprehensive knowledge of
angioedema phenotypes is crucial for correct diagnosis and choosing the appropriate …

Hereditary angioedema (HAE) is a group of rare, potentially life-threatening, and frequently
debilitating diseases characterized by recurrent, and often with an unpredictable onset, of …

Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare and life-
threatening condition characterized by recurrent localized edema. We conducted a …

Allergic disease is among the most common pathologies worldwide and its prevalence has
constantly increased up to the present days, even if according to the most recent data it …

Excessive BK (bradykinin) stimulation is responsible for the exaggerated permeabilization of
the endothelium in angioedema. However, the molecular mechanisms underlying these …