This review extensively reports data from the literature concerning the complex relationships
between the stress-induced c-Jun N-terminal kinases (JNKs) and the four main cytoskeleton …

The ubiquitin-proteasome system (UPS) mediated protein degradation is crucial to maintain
quantitive and functional homeostasis of diverse proteins. Balanced cellular protein …

WDR62 mutations that result in protein loss, truncation or single amino-acid substitutions are
causative for human microcephaly, indicating critical roles in cell expansion required for …

WDR62 is a microcephaly-related, microtubule (MT)-associated protein (MAP) that localizes
to the spindle pole and regulates spindle organization, but the underlying mechanisms …

Background Parkinson's disease (PD) is a well-known neurodegenerative disease that is
usually caused by the progressive loss of dopamine neurons and the formation of Lewy …

Stress is considered as a major cause of depression. C-Jun N-terminal kinase (JNK) is a
member of the stress-induced mitogen activated protein (MAP) kinase family which is often …

Abstract C-Jun-N-terminal-kinases (JNKs), members of the mitogen-activated-protein-kinase
family, are significantly linked with neurological and neurodegenerative pathologies and …

The c-Jun N-terminal kinase (JNK) is highly evolutionarily conserved and plays important
roles in a broad range of physiological and pathological processes. The WD40-repeat …

The stem cells of neurogenesis and carcinogenesis share many properties, including
proliferative rate, an extensive replicative potential, the potential to generate different cell …

Brain size abnormality is correlated with an increased frequency of autism spectrum disorder
(ASD) in offspring. Genetic analysis indicates that heterozygous mutations of the WD repeat …