All processes that occur within living organisms are intimately linked to biological
macromolecules such as proteins, nucleic acids, or polysaccharides. Phospholipid …

The applications of organic matrices for matrix assisted laser desorption/ionization mass
spectrometry (MALDI-MS) are reviewed. Recent advances of MALDI-MS using organic …

Integration of multiomics at the single-cell level allows the unambiguous dissecting of
phenotypic heterogeneity at different states such as health, disease, and biomedical …

The systematic study of the temperature and pressure dependence of matrix-assisted
ionization (MAI) led us to the discovery of the seemingly impossible, initially explained by …

Imaging of specific small molecules is particularly challenging using conventional optical
microscopy techniques. This has led to the development of alternative imaging modalities …

Due to their involvement in numerous biochemical pathways, neuropeptides have been the
focus of many recent research studies. Unfortunately, classic analytical methods, such as …

Covering: 2013 The ability to transfer molecular species to the gas phase and ionize them is
central to the study of natural products and other molecular species by mass spectrometry …

Nanospray desorption electrospray ionization (nano-DESI) combined with tandem mass
spectrometry (MS/MS), high-resolution mass analysis of the fragment ions (m/Δ m= 17 500 at …

This Tutorial is to provide a summary of parameters useful for successful outcomes of
laserspray ionization (LSI) and related methods that employ a laser to ablate a matrix …

In biological mass spectrometry (MS), two ionization techniques are predominantly
employed for the analysis of larger biomolecules, such as polypeptides. These are nano …