[HTML][HTML] Red blood cell storage lesion: causes and potential clinical consequences
T Yoshida, M Prudent, A D'Alessandro - Blood Transfusion, 2019 - ncbi.nlm.nih.gov
Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …
Red blood cell metabolism in vivo and in vitro
Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …
[HTML][HTML] Red blood cell storage time and transfusion: current practice, concerns and future perspectives
M García-Roa, M del Carmen Vicente-Ayuso… - Blood …, 2017 - ncbi.nlm.nih.gov
Red blood cells (RBCs) units are the most requested transfusion product worldwide.
Indications for transfusion include symptomatic anaemia, acute sickle cell crisis, and acute …
Indications for transfusion include symptomatic anaemia, acute sickle cell crisis, and acute …
A three‐minute method for high‐throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways
Rationale The implementation of mass spectrometry (MS)‐based metabolomics is
advancing many areas of biomedical research. The time associated with traditional …
advancing many areas of biomedical research. The time associated with traditional …
Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase …
Red blood cell (RBC) storage in the blood bank promotes the progressive accumulation of
metabolic alterations that may ultimately impact the erythrocyte capacity to cope with oxidant …
metabolic alterations that may ultimately impact the erythrocyte capacity to cope with oxidant …
Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes
Mature red blood cells (RBCs) lack mitochondria and thus exclusively rely on glycolysis to
generate adenosine triphosphate (ATP) during aging in vivo or storage in blood banks …
generate adenosine triphosphate (ATP) during aging in vivo or storage in blood banks …
Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage
Hypoxanthine catabolism in vivo is potentially dangerous as it fuels production of urate and,
most importantly, hydrogen peroxide. However, it is unclear whether accumulation of …
most importantly, hydrogen peroxide. However, it is unclear whether accumulation of …
Elucidating dynamic metabolic physiology through network integration of quantitative time-course metabolomics
The increasing availability of metabolomics data necessitates novel methods for deeper
data analysis and interpretation. We present a flux balance analysis method that allows for …
data analysis and interpretation. We present a flux balance analysis method that allows for …
Biomarkers defining the metabolic age of red blood cells during cold storage
Metabolomic investigations of packed red blood cells (RBCs) stored under refrigerated
conditions in saline adenine glucose mannitol (SAGM) additives have revealed the …
conditions in saline adenine glucose mannitol (SAGM) additives have revealed the …
Glucose 6-phosphate dehydrogenase deficient subjects may be better “storers” than donors of red blood cells
Storage of packed red blood cells (RBCs) is associated with progressive accumulation of
lesions, mostly triggered by energy and oxidative stresses, which potentially compromise the …
lesions, mostly triggered by energy and oxidative stresses, which potentially compromise the …