Thrombin is the key enzyme of the entire hemostatic process since it is able to exert both
procoagulant and anticoagulant functions; therefore, it represents an attractive target for the …

The thrombin binding aptamer (TBA) is a prototypical platform used to understand the impact
of chemically-modified nucleotides on aptamer stability and target affinity. To provide …

Aptamers are short oligonucleotides (DNA/RNA) or peptide molecules that can selectively
bind to their specific targets with high specificity and affinity. As a powerful new class of …

Dengue fever is one of the most common viral infections affecting humans. It is an
expanding public health problem, particularly in tropical and subtropical regions. No …

A ball resonator, positioned on the tip of an optical fiber, has been developed as a biosensor
for the prototypic detection of thrombin. The device was fabricated with a fast and repeatable …

Fluorescent nucleobases represent an important class of molecular reporters of nucleic acid
interactions. In this work, the advantages of utilizing a noncanonical fluorescent nucleobase …

Human chorionic gonadotropin (hCG) is a glycoprotein hormone used as a biomarker for
several medical conditions, including pregnancy, trophoblastic and nontrophoblastic …

Aptamers have shown potential for diagnosing clinical markers and targeted treatment of
diseases. However, their limited stability and short half-life hinder their broader applications …

For decades, nucleosides and nucleotides have formed the cornerstone of antiviral,
antiparasitic and anticancer therapeutics and have been used as tools in exploring nucleic …

Aptamers are affinity-based oligonucleotide ligands raised against a target molecule, which
might be of proteic or other nature. Aptamers are developed by using a reiterative in vitro …