The roles of extracellular vesicles in the immune system

EI Buzas - Nature Reviews Immunology, 2023 - nature.com
The twenty-first century has witnessed major developments in the field of extracellular
vesicle (EV) research, including significant steps towards defining standard criteria for the …

The biology, function, and biomedical applications of exosomes

R Kalluri, VS LeBleu - Science, 2020 - science.org
BACKGROUND All cells, prokaryotes and eukaryotes, release extracellular vesicles (EVs)
as part of their normal physiology and during acquired abnormalities. EVs can be broadly …

The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis

SF Erttmann, P Swacha, KM Aung, B Brindefalk… - Immunity, 2022 - cell.com
The microbiota are vital for immune homeostasis and provide a competitive barrier to
bacterial and fungal pathogens. Here, we investigated how gut commensals modulate …

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses

F Bayerl, P Meiser, S Donakonda, A Hirschberger… - Immunity, 2023 - cell.com
Type 1 conventional dendritic cells (cDC1s) are critical for anti-cancer immunity. Protective
anti-cancer immunity is thought to require cDC1s to sustain T cell responses within tumors …

[HTML][HTML] Biogenesis and function of extracellular vesicles in cancer

MP Bebelman, MJ Smit, DM Pegtel… - Pharmacology & …, 2018 - Elsevier
Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer
growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype …

Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications

MN Huda, M Nafiujjaman, IG Deaguero… - ACS biomaterials …, 2021 - ACS Publications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …

Analysis of extracellular vesicle DNA at the single‐vesicle level by nano‐flow cytometry

H Liu, Y Tian, C Xue, Q Niu, C Chen… - Journal of extracellular …, 2022 - Wiley Online Library
It has been demonstrated recently that extracellular vesicles (EVs) carry DNA; however,
many fundamental features of DNA in EVs (EV‐DNA) remain elusive. In this study, a …

Regulation of cGAS-and RLR-mediated immunity to nucleic acids

A Ablasser, S Hur - Nature immunology, 2020 - nature.com
Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the
structural similarity between those and host nucleic acids, mammalian cells have been able …

Bioactive DNA from extracellular vesicles and particles

EZ Malkin, SV Bratman - Cell death & disease, 2020 - nature.com
Extracellular vesicles (EVs) and particles (EPs) have recently emerged as active carriers of
molecular biomarkers and mediators of intercellular communication. While most …

The biology and function of extracellular vesicles in immune response and immunity

R Kalluri - Immunity, 2024 - cell.com
Extracellular vesicles (EVs), such as ectosomes and exosomes, contain DNA, RNA, proteins
and are encased in a phospholipid bilayer. EVs provide intralumenal cargo for delivery into …