The fibrous cap: a promising target in the pharmacotherapy of atherosclerosis

S Yanev, M Zhelyazkova-Savova… - Biomedical …, 2019 - journals.mu-varna.bg
Recent advances have shed light on the relationship between smooth muscle cell (SMC)
phenotypic modulation, resolution of inflammation and atherosclerotic plaque stability. The …

Colchicine, inflammation and fibrosis in cardiovascular disease: Merging three classical tales

GN Chaldakov - Biomedical Reviews, 2018 - journals.mu-varna.bg
Colchicine, isolated from Colchicum autumnale, is a drug for acute gouty arthritis known
from thousands of years whose use has survived to modernity. Over the past decades, the …

[PDF][PDF] Homage to George E. Palade Cell Protein Secretion in Vascular Biology: Overview and Updates

GN Chaldakov, L Aloe, A Kádár, P Ghenev… - Acta Biologica …, 2021 - sciendo.com
This short overview and updates expresses our brain-and-heart homage to George Emil
Palade," the most influential cell biologist ever". In his 1971 paper Palade wrote for Albert …

Phenotypic modulation of smooth muscle cells and matrix metalloproteinases as targets for atherosclerotic plaque stabilization

GN Chaldakov, MD Zhelyazkova-Savova… - Biomedical …, 2020 - journals.mu-varna.bg
Atherosclerosis and its complications, erosion and rupture of the plaque fibrous cap, lead to
myocardial infarction and stroke, the main causes of mortality worldwide. In this setting …

Colchicine and therapy of cardiovascular disease: Not merely a theory

GN Chaldakov, MD Zhelyazkova-Savova… - Biomedical …, 2023 - journals.mu-varna.bg
The cytoskeleton is a sophisticated cellular machinery consisted of actin filaments,
intermediate filaments and microtubules (MT) accompanied by a large number of associated …

Is there a common therapeutical strategy for bone joints and blood vessels?

V Obretenov, S Yanev… - Biomedical …, 2022 - journals.mu-varna.bg
Growing evidence demonstrated recently a rationale for the use of orally administered
collagen hydrolysate (collagen peptides) in the therapy of patients with osteoarthritis or other …

Quo vadis, atherogenesis? Part 2. Tunica adiposa-the new player in the process of atherogenesis

PI Ghenev, G Rančić, P Panayotov, M Fiore… - …, 2018 - journals.mu-varna.bg
Today, atherosclerosis is considered an immune-mediated inflammatory disease featured
by endothelial dysfunction (intimal thickening), medial atrophy, and adventitial lesions …