Adverse effects of psychedelics: From anecdotes and misinformation to systematic science

AK Schlag, J Aday, I Salam… - Journal of …, 2022 - journals.sagepub.com
Background: Despite an increasing body of research highlighting their efficacy to treat a
broad range of medical conditions, psychedelic drugs remain a controversial issue among …

[HTML][HTML] Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review

M van Elk, DB Yaden - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD

C Cao, X Barros-Álvarez, S Zhang, K Kim, MA Dämgen… - Neuron, 2022 - cell.com
Summary Serotonin (5-hydroxytryptamine [5-HT]) 5-HT2-family receptors represent essential
targets for lysergic acid diethylamide (LSD) and all other psychedelic drugs. Although the …

The subjective effects of psychedelics may not be necessary for their enduring therapeutic effects

DE Olson - ACS Pharmacology & Translational Science, 2020 - ACS Publications
Psychedelics represent one of the most promising classes of experimental medicines for the
treatment of neuropsychiatric disorders due to their ability to promote neural plasticity and …

Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern‐era clinical studies

KAA Andersen, R Carhart‐Harris… - Acta Psychiatrica …, 2021 - Wiley Online Library
Objective To conduct a systematic review of modern‐era (post‐millennium) clinical studies
assessing the therapeutic effects of serotonergic psychedelics drugs for mental health …

Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials

JS Aday, BD Heifets, SD Pratscher, E Bradley… - …, 2022 - Springer
Rationale Psychedelic research continues to garner significant public and scientific interest
with a growing number of clinical studies examining a wide range of conditions and …

Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms

A Inserra, D De Gregorio, G Gobbi, M Nader - Pharmacological Reviews, 2021 - Elsevier
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Self-blinding citizen science to explore psychedelic microdosing

B Szigeti, L Kartner, A Blemings, F Rosas, A Feilding… - elife, 2021 - elifesciences.org
Microdosing is the practice of regularly using low doses of psychedelic drugs. Anecdotal
reports suggest that microdosing enhances well-being and cognition; however, such …

Psychedelic psychiatry's brave new world

D Nutt, D Erritzoe, R Carhart-Harris - Cell, 2020 - cell.com
After a legally mandated, decades-long global arrest of research on psychedelic drugs,
investigation of psychedelics in the context of psychiatric disorders is yielding exciting …

Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects

F Holze, P Vizeli, L Ley, F Müller, P Dolder… - …, 2021 - nature.com
Growing interest has been seen in using lysergic acid diethylamide (LSD) in psychiatric
research and therapy. However, no modern studies have evaluated subjective and …