Mitochondrial dysfunction and excessive inflammatory responses are both sufficient to
induce pathology in age-dependent neurodegenerations. However, emerging evidence …

Amyloid-β (Aβ) accumulations have been identified in the retina for neurodegeneration-
associated disorders like Alzheimer's disease (AD), glaucoma, and age-related macular …

Dysregulation of the complement system is implicated in neurodegeneration, including
human and animal glaucoma. Optic nerve and retinal damage in glaucoma is preceded by …

Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs) and
leads to progressive vision loss. The first pathological signs can be seen at the optic nerve …

The aim of this paper was to investigate the effects of semaglutide on phosphorylated
protein expression, and its neuroprotective mechanism in hippocampi of high-fat-diet …

Glaucoma is a complex multifactorial eye disease manifesting in retinal ganglion cell (RGC)
death and optic nerve degeneration, ultimately causing irreversible vision loss. Research in …

Purpose: Reoxygenation after hypoxia can increase reactive oxygen species and
upregulate autophagy. We determined, for the first time, the impact of elevated IOP on …

Although elevated intraocular pressure (IOP) and age are major risk factors for glaucoma,
their effects on glaucoma pathogenesis remain unclear. This study examined the onset and …

Retinal ganglion cells (RGCs) apoptosis and their axon degeneration are pivotal features in
glaucoma. Previous studies suggest that the process of RGCs soma degeneration is distinct …

Glaucoma is a group of optic neuropathies associated with aging and sensitivity to
intraocular pressure (IOP). The disease causes vision loss through the degeneration of …